PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82816	Bromo-C10-OBn	78277-30-2	Bromo-C10-OBn is a PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTAC.
V80040	Bromo-C4-PEG4-t-butyl ester		Bromo-C4-PEG4-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82806	Bromo-PEG1-NH2 hydrobromide	2287287-20-9	Bromo-PEG1-NH2 HBr is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78555	Bromo-PEG10-t-butyl ester		Bromo-PEG10-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78556	Bromo-PEG12-acid		Bromo-PEG12-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78087	Bromo-PEG12-t-butyl ester		Bromo-PEG12-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82812	Bromo-PEG2-acetic acid	2409962-85-0	Bromo-PEG2-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V17096	Bromo-PEG2-azide	530151-56-5	Bromo-PEG2-azide is a PEG analogue containing a bromide group and a terminal azide.
V78557	Bromo-PEG2-NH2 hydrobromide		Bromo-PEG2-NH2 HBr is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82702	Bromo-PEG2-NHSester	2148295-96-7	Bromo-PEG2-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82823	Bromo-PEG2-THP	152065-54-8	Bromo-PEG2-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78558	Bromo-PEG3-CO-NH2		Bromo-PEG3-CO-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82862	Bromo-PEG4-MS	2167807-41-0	Bromo-PEG4-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82682	Bromo-PEG4-NHSester	2148295-98-9	Bromo-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78559	Bromo-PEG4-PFP ester		Bromo-PEG4-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80104	Bromo-PEG5-CH2COOtBu		Bromo-PEG5-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V82695	Bromo-PEG7-alcohol	86220-35-1	Bromo-PEG7-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80101	Bromo-PEG7-amine		Bromo-PEG7-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category.
V82773	Bromo-PEG7-azide	1056969-61-9	Bromo-PEG7-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V79507	Bromo-PEG7-Boc		Bromo-PEG7-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.