PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V79745	Bromo-PEG7-CH2COOtBu		Bromo-PEG7-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V79306	Bromo-PEG8-CH2COOtBu		Bromo-PEG8-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V78560	Bromo-PEG9-Boc		Bromo-PEG9-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78971	Bromoacetamido-PEG8-t-butyl acetate		Bromoacetamido-PEG8-t-butyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78554	Bromoacetic-PEG1-CH2-NHS ester		Bromoacetic-PEG1-CH2-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80339	Bromoacetic-PEG2-NHS ester		Bromoacetic-PEG2-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78592	C18-PEG13-acid		C18-PEG13-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category.
V82802	Cereblon inhibitor 2	2639380-62-2	Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor that may be utilized in solid tumor research, especially in breast cancer.
V82996	CFT1946	2882165-79-7	CFT1946 is an orally bioactive and selective BRAF kinase targeting ligand.
V78737	CG-PEG5-azido		CG-PEG5-azido is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V78740	CH2COOH-PEG12-CH2COOH		CH2COOH-PEG12-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82870	CH2COOH-PEG3-CH2COOH	32775-08-9	CH2COOH-PEG3-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82867	CH2COOH-PEG6-CH2COOH	83824-29-7	CH2COOH-PEG6-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82723	CH2COOH-PEG9-CH2COOH	2250056-46-1	CH2COOH-PEG9-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82705	Chloro-PEG5-chloride	5197-65-9	Chloro-PEG5-chloride is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82837	Chloroacetamido-C4-NHBoc	133264-58-1	Chloroacetamido-C4-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V78145	CHO-PEG12-Boc		CHO-PEG12-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82829	cIAP1 ligand 4	2891589-73-2	cIAP1 ligand 4 is a ligand for E3 ligase and may be utilized to prepare PROTAC.
V82958	Cl-PEG2-acid	170304-76-4	Cl-PEG2-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82734	Cl-PEG6-acid	2365309-92-6	Cl-PEG6-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.