PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82932	CRBN-6-5-5-VHL	2362575-45-7	CRBN-6-5-5-VHL is a potent and specific von Hippel-Lindau E3 ligand-based cereblon (CRBN) degrader with DC50 of 1.5 nM and little degradation of the substrates IKZF1 and IKZF3 Influence.
V82704	Cyclohexane-PEG1-Br	131665-94-6	Cyclohexane-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82853	DBCO-PEG12-acid	2754384-72-8	DBCO-PEG12-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82939	DBCO-PEG12-NHSester	2093934-94-0	DBCO-PEG12-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77702	DBCO-PEG13-NHSester		DBCO-PEG13-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V79023	DBCO-PEG3-amide-N-Fmoc		DBCO-PEG3-amide-N-Fmoc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82859	DBCO-PEG3-amine	2093409-57-3	DBCO-PEG3-amine is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82878	DBCO-PEG5-acid	2764923-65-9	DBCO-PEG5-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82822	DBCO-PEG8-acid	2765066-35-9	DBCO-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82906	DBCO-PEG8-NHSester	2553412-88-5	DBCO-PEG8-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82969	dCeMM1	118719-16-7	dCeMM1 is an RBM39 molecular glue degrader.
V83014	Desmorpholinyl Quizartinib-PEG2-COOH	2292116-14-2	Desmorpholinyl Quizartinib-PEG2-COOH contains the target protein FLT-3 ligand and a PEG-based PROTAC (PROteolysis TArgeting Chimera) linker.
V77087	Desthiobiotin-PEG4-acid		Desthiobiotin-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82890	Desthiobiotin-PEG4-propargyl	1951424-89-7	Desthiobiotin-PEG4-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82721	Diethylene glycol diacetate	628-68-2	Diethylene glycol diacetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77801	Dimethylamine-PEG19		Dimethylamine-PEG19 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79142	Dimethylamino-PEG11		Dimethylamino-PEG11 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77071	DOTA-PEG5-C6-DBCO		DOTA-PEG5-C6-DBCO is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V83002	Dovitinib-RIBOTAC TFA	2759351-69-2	Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves precursor-miR-21 with great potency and selectivity.
V82968	DSPE-PEG-Biotin (MW 2000)	385437-57-0	DSPE-PEG-Biotin (MW 5000) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.