PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V79217	DSPE-PEG14-COOH		DSPE-PEG14-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77061	DSPE-PEG6-Mal		DSPE-PEG6-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82942	EED226-COOH	2467965-71-3	EED226-COOH is a EED226-based PROTAC target protein EED ligand, which combines with the VHL ligand through a linker to form the PRC2 degrader UNC6852 .
V79298	endo-BCN-PEG12-NH2 hydrochloride		endo-BCN-PEG12-NH2 HCl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V51007	endo-BCN-PEG4-NHS ester	2252422-32-3	endo-BCN-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82851	F-PEG2-COOH	2383964-72-3	F-PEG2-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79512	F-PEG2-S-Boc		F-PEG2-S-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77521	F-PEG2-S-COOH		F-PEG2-S-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77520	F-PEG2-SO-COOH		F-PEG2-SO-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V79513	F-PEG2-SO2-COOH		F-PEG2-SO2-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V79387	FA-PEG5-Mal (Folic acid-PEG5-Mal)		FA-PEG5-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V79475	Fmoc-Gly-Gly-(D-Phe)-Gly-CH2-O-CH2-Cbz		Fmoc-Gly-Gly-(D-Phe)-Gly-CH2-O-CH2-Cbz is a PROTAC (PROteolysis TArgeting Chimera) linker and a maleimide-GGFG peptide linker.
V82989	Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz	2264011-97-2	Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz is a PROTAC (PROteolysis TArgeting Chimera) linker and a maleimide-GGFG peptide linker.
V82913	Fmoc-Gly-NH-CH2-O-CH2-Cbz	1599440-07-9	Fmoc-Gly-NH-CH2-O-CH2-Cbz is a PROTAC (PROteolysis TArgeting Chimera) linker and a maleimide-GGFG peptide linker.
V82904	Fmoc-N-amido-PEG2-alcohol	299430-87-8	Fmoc-N-amido-PEG2-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79676	Fmoc-N-amido-PEG2-azide		Fmoc-N-amido-PEG2-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V21187	Fmoc-N-amido-PEG3-acid	867062-95-1	Fmoc-N-amido-PEG3-acid is a PEG analogue containing an Fmoc-protected amine and a terminal carboxylic acid.
V82830	Fmoc-N-amido-PEG3-azide	1172605-58-1	Fmoc-N-amido-PEG3-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V79483	Fmoc-N-amido-PEG36-Boc		Fmoc-N-amido-PEG36-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78802	Fmoc-N-amido-PEG4-amine		Fmoc-N-amido-PEG4-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.