PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82624	Fmoc-N-amido-PEG5-azide	2924480-17-9	Fmoc-N-amido-PEG5-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78407	Fmoc-N-amido-PEG6-amine		Fmoc-N-amido-PEG6-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82857	Fmoc-NH-PEG11-CH2COOH	2629308-66-1	Fmoc-NH-PEG11-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77757	Fmoc-NH-PEG14-acid		Fmoc-NH-PEG14-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79487	Fmoc-NH-PEG5-NH-Boc		Fmoc-NH-PEG5-NH-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79492	Fmoc-PEG10-NHSester		Fmoc-PEG10-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78348	Fmoc-PEG5-NHBoc		Fmoc-PEG5-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77861	Fmoc-PEG9-NHSester		Fmoc-PEG9-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82712	FmocNH-PEG4-t-butyl acetate	894427-95-3	FmocNH-PEG4-t-butyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82821	FmocNH-PEG4-t-butyl ester	2148295-94-5	FmocNH-PEG4-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82902	Glutarimide-Isoindolinone-NH-PEG2-COOH	2803827-03-2	Glutarimide-Isoindolinone-NH-PEG2-COOH is a ligand (for E3 ligase )-linker conjugate containing cereblon ligand and 1 linker.
V82886	Glutarimide-Isoindolinone-NH-PEG3-COOH	2803819-65-8	Glutarimide-Isoindolinone-NH-PEG3-COOH is a ligand (for E3 ligase )-linker conjugate containing cereblon ligand and 1 linker.
V82900	Glutarimide-Isoindolinone-NH-PEG4-COOH	2927334-86-7	Glutarimide-Isoindolinone-NH-PEG4-COOH is a ligand (for E3 ligase )-linker conjugate containing cereblon ligand and 1 linker.
V79619	Glycocholic acid-PEG10-iodoacetamide		Glycocholic acid-PEG10-iodoacetamide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82988	H2N-PEG2-CH2COOtBu	1122484-77-8	H2N-PEG2-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82777	Halo PROTAC 1	2241668-45-9	Halo PROTAC 1 is a composite molecule connected by E3 ligand to 22 atoms, and the linker of the linker is a Halogen group.
V76920	HO-PEG-CH2COOH (MW 10000)		HO-PEG-CH2COOH (MW 10000) is a PEG polymer with -COOH that can be used as a PROTAC (PROteolysis TArgeting Chimera) linker to prepare PROTACs.
V76919	HO-PEG-CH2COOH (MW 35000)		HO-PEG-CH2COOH (MW 35000) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82911	HO-PEG18-OH	4445-03-8	HO-PEG18-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V79578	Hydrazide-PEG4-Desthiobiotin		Hydrazide-PEG4-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.