PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V77908	Hydroxy-PEG14-t-butyl ester		Hydroxy-PEG14-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80451	Hydroxy-PEG2-CH2CH2COO-PEG2-propionic acid		Hydroxy-PEG2-CH2CH2COO-PEG2-propionic acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V6815	Hydroxy-PEG2-t-butyl ester	133803-81-3	Hydroxy-PEG2-t-butyl ester is a PEG analogue containing a hydroxyl group with a t-butyl ester.
V82762	Hydroxy-PEG24-Boc	2490419-62-8	Hydroxy-PEG24-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82722	Hydroxy-PEG3-ethyl acetate	118988-04-8	Hydroxy-PEG3-ethyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82680	Hydroxy-PEG3-MS	139115-89-2	Hydroxy-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V22329	Hydroxy-PEG3-t-butyl ester	186020-66-6	Hydroxy-PEG3-t-butyl ester is a PEG analogue containing a hydroxyl group with a t-butyl ester.
V82759	Hydroxy-PEG4-CH2COOH sodium salt	73349-20-9	Hydroxy-PEG4-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82864	Hydroxy-PEG4-methyl acetate	77303-64-1	Hydroxy-PEG4-methyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V22333	Hydroxy-PEG4-t-butyl ester	518044-32-1	Hydroxy-PEG4-t-butyl ester is a PEG analogue containing a hydroxyl group with a t-butyl ester.
V82831	I-PEG5-OH	1883516-31-1	I-PEG5-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82752	ICG-Sulfo-OSu sodium	190714-28-4	ICG-Sulfo-OSu sodium is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V76886	Iodo-PEG7-alcohol		Iodo-PEG7-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V76887	Iodoacetamide-PEG5-azide		Iodoacetamide-PEG5-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V80386	Iodoacetamide-PEG5-NH-Boc		Iodoacetamide-PEG5-NH-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80385	Iodoacetamide-PEG5-NH2		Iodoacetamide-PEG5-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80387	Iodoacetamido-PEG6-acid		Iodoacetamido-PEG6-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80388	Iodoacetyl-PEG4-biotin		Iodoacetyl-PEG4-biotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82707	Iodoacetyl-PEG4-NHS ester	2517899-65-7	Iodoacetyl-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80389	Iodoacetyl-PEG8-biotin		Iodoacetyl-PEG8-biotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.