PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82652	Ipatasertib-NH2 dihydrochloride (GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)	1001264-73-8	Ipatasertib-NH2 di-HCl is a ligand for the PROTAC (INY-03-041) target protein AKT.
V82626	K-Ras ligand-Linker Conjugate 1	2749492-84-8	K-Ras ligand-Linker Conjugate 1 contains the target protein K-Ras ligand and PROTAC (PROteolysis TArgeting Chimera) linker, which can recruit E3 ligases (such as VHL, CRBN, MDM2 and IAP).
V82640	K-Ras ligand-Linker Conjugate 2	2741300-61-6	K-Ras ligand-Linker Conjugate 2 contains the target protein K-Ras ligand and PROTAC (PROteolysis TArgeting Chimera) linker, which can recruit E3 ligases (such as VHL, CRBN, MDM2 and IAP).
V82938	KB02-COOH	2375196-30-6	KB02-COOH is a synthetic fragment of the ubiquitin E3 ligase ligand KB02.
V82916	L-Homopropargylglycine hydrochloride	942518-19-6	L-Homopropargylglycine HCl is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the alkyl chain class and may be utilized to prepare PROTAC molecules.
V82979	Lenalidomide-4-OH	1061604-41-8	Lenalidomide-4-OH is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82786	Lenalidomide-5-aminomethyl	1010100-28-3	Lenalidomide-5-aminomethyl is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82946	Lenalidomide-5-aminomethyl hydrochloride	1158264-69-7	Lenalidomide-5-aminomethyl HCl is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82924	Lenalidomide-5-Br	1010100-26-1	Lenalidomide-5-Br is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V83010	Lenalidomide-6-F	2468780-87-0	Lenalidomide-6-F is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82991	Lenalidomide-acetylene-C5-COOH (Cereblon ligand-linker Conjugate)	2429878-72-6	Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is a Lenalidomide-based Cereblon ligand that recruits CRBN protein.
V83005	Lenalidomide-C4-NH2 hydrochloride (Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride)	2435715-90-3	Lenalidomide-C4-NH2 HCl is a Lenalidomide-based Cereblon ligand that recruits CRBN protein.
V82852	Lenalidomide-C5-amido-Boc	2138441-25-3	Lenalidomide-C5-amido-Boc is a Lenalidomide-based Cereblon ligand that recruits CRBN protein.
V82917	Lenalidomide-C5-NH2 hydrochloride	2595367-27-2	Lenalidomide-C5-NH2 HCl is a Lenalidomide-based Cereblon ligand that recruits CRBN protein.
V82637	Lenalidomide-C5-NH2 TFA	2550398-71-3	Lenalidomide-C5-NH2 HCl is a Lenalidomide-based Cereblon ligand that recruits CRBN protein.
V82950	Lenalidomide-I	2207541-30-6	Lenalidomide-I is an analogue of the cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase and is used for recruitment of CRBN proteins.
V82636	Lenalidomide-PEG3-iodine	2738934-13-7	Lenalidomide-PEG3-iodine is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Lenalidomide-based cereblon ligand and a 3-unit linker.
V83013	Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride	2748150-20-9	Lenalidomide-propargyl-C2-amido-Ph-NH2 HCl binds the E3 ubiquitin ligase ligand cereblon (CRBN).
V82764	m-PEG-NHS ester (MW 10000)	92451-01-9	m-PEG-NHS ester (MW 10000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82701	m-PEG-NHS ester (MW 20000)	92451-01-9	m-PEG-NHS ester (MW 20000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.