PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V82887 | m-PEG-NHS ester (MW 5000) (mPEG-SC (MW 5000); mPEG-Succinimidyl ester (MW 5000)) | 92451-01-9 | m-PEG-NHS ester (MW 5000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V82725 | m-PEG10-NHSester | 2490419-63-9 | m-PEG10-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80820 | m-PEG1000-CH2COOH | m-PEG1000-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
|
V82741 | m-PEG12-Mal | 2853560-28-6 | m-PEG12-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V82895 | m-PEG12-Thiol | 2413368-61-1 | m-PEG12-Thiol is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80822 | m-PEG13-azide | m-PEG13-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. | |
|
V80823 | m-PEG14-NHSester | m-PEG14-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
|
V82848 | m-PEG15-acetic acid | 2417256-16-5 | m-PEG15-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80824 | m-PEG15-COOH | m-PEG15-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V80825 | m-PEG18-acid | m-PEG18-acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
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V80826 | m-PEG18-Mal | m-PEG18-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82866 | m-PEG2-amido-Ph-NH2 | 1284417-66-8 | m-PEG2-amido-Ph-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82750 | m-PEG2-O-Ph-3-NH2 | 126415-02-9 | m-PEG2-O-Ph-3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82749 | m-PEG2-O-Ph-NH2 | 65673-48-5 | m-PEG2-O-Ph-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82778 | m-PEG20-alcohol | 1059605-06-9 | m-PEG20-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80827 | m-PEG21-OH | m-PEG21-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82986 | m-PEG24-azide | 2563873-82-3 | m-PEG24-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V82901 | m-PEG24-Mal | 2579693-28-8 | m-PEG24-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V25849 | m-PEG3-amine | 74654-07-2 | m-PEG3-amine is a PEG analogue containing an amino group. |
|
V82785 | m-PEG37-acid | 2924199-92-6 | m-PEG37-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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