PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V25864 | m-PEG4-acid | 67319-28-2 | m-PEG4-acid is a PEG analogue containing a terminal carboxylic acid. |
|
V76749 | m-PEG4-PFP ester | m-PEG4-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82784 | m-PEG4-phosphonic acid | 1872433-62-9 | m-PEG4-phosphonic acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82727 | m-PEG48-amine | 2416858-25-6 | m-PEG48-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V79983 | m-PEG5-amino-Mal | m-PEG5-amino-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V25910 | m-PEG6-alcohol | 23601-40-3 | m-PEG6-alcohol is a PEG analogue containing a hydroxyl group. |
|
V80828 | m-PEG6-Boc | m-PEG6-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V80830 | m-PEG7-Silane | m-PEG7-Silane is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
|
V80829 | m-PEG750-Br | m-PEG750-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
|
V80831 | m-PEG8-amide-C10-Thiol | m-PEG8-amide-C10-Thiol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82817 | m-PEG9-acid | 2576495-35-5 | m-PEG9-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V78628 | m-PEG9-Mal | m-PEG9-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82760 | m-PEGn-NHSester | 174569-25-6 | m-PEGn-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
|
V82679 | Mal-amido-PEG10-acid | 2785355-74-8 | Mal-amido-PEG10-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80665 | Mal-amido-PEG15-acid | Mal-amido-PEG15-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category. | |
|
V82686 | Mal-amido-PEG3-acid | 2055353-75-6 | Mal-amido-PEG3-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80534 | Mal-amido-PEG3-alcohol | Mal-amido-PEG3-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category. | |
|
V82842 | Mal-amido-PEG3-NHS ester | 2055353-77-8 | Mal-amido-PEG3-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V79769 | Mal-amido-PEG5-acid | Mal-amido-PEG5-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V80666 | Mal-amido-PEG7-NHS ester | Mal-amido-PEG7-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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