PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82804	Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride	174422-72-1	Mal-C2-cyclohexylcarboxyl-hydrazide HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl chain class, may be utilized to prepare PROTAC protein degraders.
V76794	Mal-NH-PEG8-Boc		Mal-NH-PEG8-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80668	Mal-PEG10-acid		Mal-PEG10-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78089	Mal-PEG10-Boc		Mal-PEG10-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V76793	Mal-PEG10-NHSester		Mal-PEG10-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82745	Mal-PEG12-acid	2445165-75-1	Mal-PEG12-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80669	Mal-PEG12-CHO		Mal-PEG12-CHO is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82808	Mal-PEG12-NH-Boc	2170654-80-3	Mal-PEG12-NH-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82871	Mal-PEG2-NH2 TFA	660843-23-2	Mal-PEG2-NH2 (TFA) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80670	Mal-PEG25-NH2 hydrochloride		Mal-PEG25-NH2 HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82720	Mal-PEG3-NH2 TFA	2830214-77-0	Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG cross-linker with maleimide and amine.
V80199	Mal-PEG3-O-Ac		Mal-PEG3-O-Ac is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82623	Mal-PEG4-C2-NH2 TFA	2512227-13-1	Mal-PEG4-C2-NH2 TFA is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82795	Mal-PEG5-C2-NH2 hydrochloride	2454216-21-6	Mal-PEG5-C2-NH2 HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80743	Me-PEG18-NH2		Me-PEG18-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82879	Me-PEG4-Me	143-24-8	Me-PEG4-Me is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82983	Methyl 3-hydroxypropanoate	6149-41-3	Methyl 3-hydroxypropanoate is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V82709	Methyl acetate-PEG1	58349-37-4	Methyl acetate-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80895	Methyl acetate-PEG2-propanol		Methyl acetate-PEG2-propanol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82713	Methyl-PEG2-alcohol	111-77-3	Methyl-PEG2-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.