PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V80885 | Methylacetamide-PEG3-NH2 | Methylacetamide-PEG3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82736 | Methylamino-PEG3-acid | 2148295-95-6 | Methylamino-PEG3-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80759 | Methylamino-PEG7-benzyl | Methylamino-PEG7-benzyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V76762 | ML 2-14 | ML 2-14 is a PROTAC for BRD4 degradation with a C4 alkyl linker. | |
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V82693 | MS-PEG10-THP | 42607-91-0 | MS-PEG10-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V82698 | MS-PEG12-THP | 552886-58-5 | MS-PEG12-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V82791 | Ms-PEG3-CH2CH2COOH | 2306832-21-1 | Ms-PEG3-CH2CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V80198 | Ms-PEG3-NHS ester | Ms-PEG3-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82775 | MS-PEG4-t-butyl ester | 1024602-74-1 | MS-PEG4-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80228 | MS-PEG5-THP | MS-PEG5-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
|
V79299 | MS-PEG8-THP | MS-PEG8-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
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V82761 | MS6105 | 2891709-58-1 | MS6105 is an LDH proteolytic targeting chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anti-neoplastic activity. |
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V76730 | N-(Amino-PEG2)-N-bis(PEG3-azide) | N-(Amino-PEG2)-N-bis(PEG3-azide) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
|
V82788 | N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 | 2839527-02-3 | N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80891 | N-Acetylpyrrolidine-PEG2-Br | N-Acetylpyrrolidine-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V80901 | N-bis(t-boc-N-amido-PEG3)-N-(PEG3-acid) (hydrochloride) | N-bis(t-boc-N-amido-PEG3)-N-(PEG3-acid) HCl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. | |
|
V82944 | N-Boc-C1-PEG3-C3-NH2 | 194920-62-2 | N-Boc-C1-PEG3-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82726 | N-Boc-C1-PEG5-C3-NH2 | 956472-77-8 | N-Boc-C1-PEG5-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82683 | N-Boc-PEG-t-butyl ester | 145119-18-2 | N-Boc-PEG-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V26295 | N-Boc-PEG3-alcohol | 139115-92-7 | N-Boc-PEG3-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group. |
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