PROTAC Linkers

+MORE

PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V80902	N-Boc-PEG3-t-butyl ester		N-Boc-PEG3-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V26297	N-Boc-PEG4-alcohol	106984-09-2	N-Boc-PEG4-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V26299	N-Boc-PEG5-alcohol	1404111-67-6	N-Boc-PEG5-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V26300	N-Boc-PEG6-alcohol	331242-61-6	N-Boc-PEG6-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V82849	N-Deshydroxyethyl Dasatinib-d8	1189998-96-6	N-Deshydroxyethyl Dasatinib-d8 is the deuterated form of N-Deshydroxyethyl Dasatinib.
V80408	N-Ethyl-3,3,3-trifluoro-N-methylpropanamide-PEG2-Br		N-Ethyl-333-trifluoro-N-methylpropanamide-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82685	N-Ethyl-N-methylpropionamide-PEG1-Br	1695856-63-3	N-Ethyl-N-methylpropionamide-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80929	N-Ethylacetamide-PEG1-Br		N-Ethylacetamide-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77516	N-Ethylacetamide-PEG2-Br		N-Ethylacetamide-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82728	ND1-YL2	2582803-80-1	ND1-YL2 is a PROTAC that selectively degrades SRC-1 through the N-degron pathway.
V81630	NH2-PEG-Strt (MW 10000)		NH2-PEG-Strt (MW 10000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V80942	NH2-PEG-Strt (MW 3000)		NH2-PEG-Strt (MW 3000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V78966	NH2-PEG10-C2-dimethylamino		NH2-PEG10-C2-dimethylamino is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82874	NH2-PEG2-methyl acetate	741235-80-3	NH2-PEG2-methyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82956	NH2-PEG3-C6-Cl	1261350-60-0	NH2-PEG3-C6-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80941	NH2-PEG3500-NH2		NH2-PEG3500-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V82809	NH2-PEG5-C6-Cl	1261238-22-5	NH2-PEG5-C6-Cl (K-7) is a PEG-type linker.
V82970	NH2-PEG5-C6-Cl hydrochloride	2241669-16-7	NH2-PEG5-C6-Cl HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80943	NHS ester-PEG10-COOH		NHS ester-PEG10-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80157	NHS ester-PEG3-S-methyl ethanethioate		NHS ester-PEG3-S-methyl ethanethioate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.