PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80946 | NHS-bis-PEG2-amide-Mal | NHS-bis-PEG2-amide-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V80944 | NHSester-PEG13-COOH | NHS ester-PEG13-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
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V80945 | NHSester-PEG7-COOH | NHS ester-PEG7-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
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V82719 | Nonylbenzene-PEG8-OH | 41506-14-3 | Nonylbenzene-PEG8-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V82884 | PEG3 | 67439-82-1 | PEG3 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V4561 | PF-05231023 | 1037589-69-7 | PF-05231023 is novel and potent, long-actingFGF21-receptoragonist being developed as a potential treatment for T2DM. |
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V82730 | Ph-PEG3 | 7204-16-2 | Ph-PEG3 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V79321 | Phthalimide-PEG4-MPDM-OH | Phthalimide-PEG4-MPDM-OH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. | |
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V81125 | Phthalimide-PEG4-PDM-OTBS | Phthalimide-PEG4-PDM-OTBS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. | |
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V82645 | Piperidine-GNE-049-N-Boc | 1936431-36-5 | Piperidine-GNE-049-N-Boc is a ligand for the PROTAC target protein of dCBP-1. |
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V82926 | Pomalidomide 4'-alkylC5-acid | 2225940-49-6 | Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing Pomalidomide based cereblon (CRBN) ligand and 1 linker. |
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V82934 | Pomalidomide 4'-PEG2-azide | 2271036-45-2 | Pomalidomide 4'-PEG2-azide is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a linker. |
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V82923 | Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) | 2139348-63-1 | Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a ligand (for E3 ligase )-linker conjugate containing Pomalidomide-based cereblon ligand and 5 Polyethylene glycol (PEG) units linker. |
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V82744 | Pomalidomide-6-O-CH3 | 1547163-08-5 | Pomalidomide-6-O-CH3 is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. |
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V82936 | Pomalidomide-amido-C3-COOH | 2162120-77-4 | Pomalidomide-amido-C3-COOH is a ligand (for E3 ligase )-linker conjugate containing a Pomalidomide-based cereblon ligand and a linker. |
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V82665 | Pomalidomide-amido-C4-amido-C6-NH-Boc (Cereblon Ligand-Linker Conjugates 21; E3 Ligase Ligand-Linker Conjugates 54) | 2435808-02-7 | Pomalidomide-amido-C4-amido-C6-NH-Boc is a ligand (for E3 ligase )-linker conjugate containing a Pomalidomide-based cereblon ligand and 1 linker. |
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V82662 | Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc (Cereblon Ligand-Linker Conjugates 20; E3 Ligase Ligand-Linker Conjugates 53) | 2435720-04-8 | Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a ligand (for E3 ligase )-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker. |
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V82655 | Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22; E3 ligase Ligand-Linker Conjugates 55) | 2328070-52-4 | Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate that contains a Pomalidomide-based cereblon ligand and a 3-unit PEG linker. |
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V82841 | Pomalidomide-amino-PEG3-NH2 | 2380273-74-3 | Pomalidomide-amino-PEG3-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82978 | Pomalidomide-amino-PEG3-NH2 hydrochloride | 2380273-75-4 | Pomalidomide-amino-PEG3-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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