PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82899 | Pomalidomide-amino-PEG4-NH2 | 2331259-44-8 | Pomalidomide-amino-PEG4-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V83008 | Pomalidomide-amino-PEG5-NH2 hydrochloride | 2421217-05-0 | Pomalidomide-amino-PEG5-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82903 | Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | Pomalidomide-C12-NH2 HCl is the E3 ligase (e.g. CRBN) ligand-linker conjugate of PROTAC KRAS G12C degrader-1. |
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V82803 | Pomalidomide-C4-NH2 | 1957236-34-8 | Pomalidomide-C4-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82912 | Pomalidomide-C4-NH2 hydrochloride | 2162120-73-0 | Pomalidomide-C4-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82820 | Pomalidomide-C6-O-C5-O-C4-COOH | 2375774-54-0 | Pomalidomide-C6-O-C5-O-C4-COOH is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Pomalidomide based cereblon ligand and linker. |
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V82940 | Pomalidomide-C7-COOH | 2225940-51-0 | Pomalidomide-C7-COOH is a ligand (for E3 ligase )-linker conjugate and an intermediate in the preparation /synthesis of PROTAC BCL-XL degrader. |
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V82877 | Pomalidomide-C7-NH2 hydrochloride (Pomalidomide 4'-alkylC7-amine hydrochloride) | 2446474-05-9 | Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) HCl is an E3 ligase (e.g. CRBN) ligand-linker conjugate. |
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V82928 | Pomalidomide-PEG1-C2-COOH | 2139348-60-8 | Pomalidomide-PEG1-C2-COOH is a ligand (for E3 ligase )-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 unit PEG linker. |
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V82925 | Pomalidomide-PEG1-C2-N3 (Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50) | 2271036-44-1 | Pomalidomide-PEG1-C2-N3 is a synthetic E3 ligase (e..g. CRBN) ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 1-unit PEG linker. |
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V82954 | Pomalidomide-PEG2-azide | 2267306-14-7 | Pomalidomide-PEG2-azide is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker. |
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V82922 | Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) | 2140807-17-4 | Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate that contains a Pomalidomide-based cereblon ligand and linker. |
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V82643 | Pomalidomide-PEG2-Tos | 2599846-07-6 | Pomalidomide-PEG2-Tos is an E3 ligase ligand-linker coupling based on PROTAC technology, consisting of cereblon ligand and 2 PEG (polyethylene glycol) units linker. |
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V82929 | Pomalidomide-PEG3-azide | 2267306-15-8 | Pomalidomide-PEG3-azide is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing a Pomalidomide-based cereblon ligand and a 3-unit PEG linker. |
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V82882 | Pomalidomide-PEG3-C2-NH2 hydrochloride (Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride) | 2446474-09-3 | Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82947 | Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA) | 2414913-97-4 | Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Pomalidomide based cereblon ligand and 3 Linker for unit PEG. |
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V82961 | Pomalidomide-PEG4-C2-NH2 hydrochloride | 2357105-92-9 | Pomalidomide-PEG4-C2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 4-unit PEG linker, which may be utilized to prepare PROTAC molecules. |
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V83011 | Pomalidomide-PEG6-NH2 hydrochloride | 2341841-01-6 | Pomalidomide-PEG6-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 6 PEG (polyethylene glycol) units linker, used in PROTAC technology. |
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V82676 | Propanol-PEG4-CH2OH | 156868-17-6 | Propanol-PEG4-CH2OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V80194 | Propanol-PEG5-CH2OH | Propanol-PEG5-CH2OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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