PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V80100	Propanol-PEG6-CH2OH		Propanol-PEG6-CH2OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82796	Propargyl-PEG10-alcohol	2378150-09-3	Propargyl-PEG10-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V81211	Propargyl-PEG11-acid		Propargyl-PEG11-acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V81212	Propargyl-PEG11-alcohol		Propargyl-PEG11-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78781	Propargyl-PEG11-amine		Propargyl-PEG11-amine is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V81213	Propargyl-PEG12-acid		Propargyl-PEG12-acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V81214	Propargyl-PEG13-Boc		Propargyl-PEG13-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78339	Propargyl-PEG13-OH		Propargyl-PEG13-OH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78146	Propargyl-PEG14-OH		Propargyl-PEG14-OH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V83001	Propargyl-PEG2-bromide	1287660-82-5	Propargyl-PEG2-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82889	Propargyl-PEG2-CH2COOH	944561-46-0	Propargyl-PEG2-CH2COOH is a PEG-based PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTACs.
V82966	Propargyl-PEG2-NHS ester	2512228-06-5	Propargyl-PEG2-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82757	Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite	1391728-01-0	Propargyl-PEG3-1-ob-cyanoethyl-NN-diisopropylphosphoramidite is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V80257	Propargyl-PEG4-thioacetyl		Propargyl-PEG4-thioacetyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82827	Propargyl-PEG5-azide	1589522-62-2	Propargyl-PEG5-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V80038	Propargyl-PEG7-amine		Propargyl-PEG7-amine is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V81215	Propargyl-PEG7-Br		Propargyl-PEG7-Br is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82781	Propargyl-PEG9-acid	1613752-50-3	Propargyl-PEG9-acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V81216	Propargyl-PEG9-THP		Propargyl-PEG9-THP is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V83007	Propynyl-PEG1-Ac	944561-45-9	Propynyl-PEG1-Ac is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.