PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82994	PROTAC BRD9 Degrader-4	2633632-34-3	PROTAC BRD9 Degrader-4 is a BRD9 bifunctional degrader for cancer research.
V82873	PROTAC BRD9-binding moiety 1 hydrochloride	2448414-41-1	PROTAC BRD9-binding moiety 1 HCl is a structure that can bind to BRD9 and inhibits the activity of BRD9 based on PROTAC technology.
V82672	PROTAC eDHFR Degrader-1	2849442-92-6	PROTAC eDHFR Degrader-1 is a PROTAC that effectively degrades eDHFR-YFP, a variety of POIs (including YFP and luciferase).
V82987	PROTAC IRAK4 ligand-1	2357108-39-3	PROTAC IRAK4 ligand-1 is a synthetic interleukin 1 receptor-associated kinase 4 (IRAK4) ligand.
V4743	PROTAC Linker 4	1799506-30-1	PROTAC Linker 4 is a non-peptide (small molecule)linker used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
V82844	PROTAC PTK6 ligand-1	2408341-98-8	PROTAC PTK6 ligand-1 is an intermediate in the synthesis/preparation of BTK kinase inhibitors.
V82776	PROTAC TTK degrader-1	2953426-43-0	PROTAC TTK degrader-1 is a potent TTK (threonine tyrosine kinase) PROTAC degrader with DC50s of 1.7 and 5.8 nM in COLO-205 and HCT-116 cells, respectively.
V82811	Pyrene Azide 3	2252168-06-0	Pyrene azide 3 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V82840	Pyrroline-5-carboxylate	2139-03-9	Pyrroline-5-carboxylate is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V81297	Rhodamine B PEG2-NH2		Rhodamine B PEG2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82813	S-acetyl-PEG4-NHBoc	1404111-70-1	S-acetyl-PEG4-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80256	S-acetyl-PEG4-Thiol		S-acetyl-PEG4-Thiol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82863	S-acetyl-PEG5-alcohol	1000415-61-1	S-acetyl-PEG5-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82959	SB1-G-187	2769753-18-4	SB1-G-187 is a PROTAC, a multikinase degrader.
V82845	SCO-PEG3-COOH	2141976-36-3	SCO-PEG3-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82714	SCO-PEG8-NHS	2143968-68-5	SCO-PEG8-NHS SCO is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82973	SR-1114	2769141-82-2	SR-1114 is a first-of-its-kind PROTAC ENL degrader.
V76469	Sulfo DBCO-PEG4-Maleimide TEA		Sulfo DBCO-PEG4-Maleimide TEA is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V81543	t-Boc-amido-PEG10-acid		t-Boc-amido-PEG10-acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82787	t-Boc-Aminooxy-PEG11-amine	1630094-83-5	t-Boc-Aminooxy-PEG11-amine is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.