PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82634	Thalidomide-4-O-C7-NH2	2093536-11-7	Thalidomide-O-C7-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82639	Thalidomide-4-O-C8-NH2	1957235-91-4	Thalidomide-O-C8-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82897	Thalidomide-4-O-C8-NH2 hydrochloride	2636798-38-2	Thalidomide-O-C8-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82780	Thalidomide-5,6-Cl	2648939-40-4	Thalidomide-5,6-Cl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82933	Thalidomide-5,6-F	1496997-41-1	Thalidomide-5,6-F is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V83004	Thalidomide-5-COOH	1216805-11-6	Thalidomide-5-COOH is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82807	Thalidomide-5-O-CH2-COOH	2467425-53-0	Thalidomide-5-O-CH2-COOH is a conjugate of E3 ligase ligand and linker consisting of Thalidomide and NH-PEG3-NH-Boc.
V82631	Thalidomide-5-PEG3-NH2	2743432-13-3	Thalidomide-5-PEG3-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82893	Thalidomide-5-PEG3-NH2 hydrochloride	2761385-81-1	Thalidomide-5-PEG3-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82630	Thalidomide-5-PEG4-NH2	2743434-16-2	Thalidomide-5-PEG4-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82880	Thalidomide-5-propargyl	2226303-74-6	Thalidomide-5-propargyl is a propargyl-modified Thalidomide that works as a Cereblon® ligand to recruit CRBN® proteins.
V82699	Thalidomide-NH-(CH2)3-NH-Boc	2093386-36-6	Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide that can serve as a Cereblon ligand to recruit CRBN proteins.
V82797	Thalidomide-NH-amido-C3-NH2	2763827-11-6	Thalidomide-NH-amido-C3-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82783	Thalidomide-NH-amido-C6-NH2	2763827-13-8	Thalidomide-NH-amido-C6-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82782	Thalidomide-NH-amido-PEG4-C2-NH2	2653336-34-4	Thalidomide-NH-amido-PEG4-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82650	Thalidomide-NH-C10-COOH	2428400-33-1	Thalidomide-NH-C10-COOH (compound 6b) is a ligand (for E3 ligase )-linker conjugate containing a Thalidomide-based von Hippel-Lindau (VHL) ligand and a linker.
V82659	Thalidomide-NH-C2-PEG3-OH	2140807-23-2	Thalidomide-NH-C2-PEG3-OH is an E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker.
V82856	Thalidomide-NH-C5-NH2	2093386-39-9	Thalidomide-NH-C5-NH2 is a synthetic E3 ligase (e.CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82976	Thalidomide-NH-C5-NH2 hydrochloride	2375194-03-7	Thalidomide-NH-C5-NH2 HCl is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker for PROTAC synthesis.
V82669	Thalidomide-NH-C6-NH2	2093386-50-4	Thalidomide-NH-C6-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.