PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82891	Thalidomide-NH-C6-NH2 hydrochloride	2375194-37-7	Thalidomide-NH-C6-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82869	Thalidomide-NH-C8-NH2	1957236-36-0	Thalidomide-NH-C8-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82881	Thalidomide-NH-C8-NH2 hydrochloride	2446474-06-0	Thalidomide-NH-C8-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82921	Thalidomide-NH-CH2-COOH	927670-97-1	Thalidomide-NH-CH2-COOH is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN proteins.
V82888	Thalidomide-NH-PEG1-NH2 hydrochloride	2154342-56-8	Thalidomide-NH-PEG1-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82995	Thalidomide-NH-PEG2-COOH	2412056-45-0	Thalidomide-NH-PEG2-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82993	Thalidomide-NH-PEG3-COOH	2375283-62-6	Thalidomide-NH-PEG3-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82846	Thalidomide-NH-PEG3-NH-Boc (Thalidomide-NH-PEG3-NH-BOC)	2204246-03-5	Thalidomide-NH-PEG3-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide and NH-PEG3-NH-Boc.
V82941	Thalidomide-NH-PEG3-propionic acid	2138440-82-9	Thalidomide-NH-PEG3-propionic acid is a ligand (for E3 ligase )-linker conjugate that combines a Thalidomide-based Cereblon ligand with a 3-unit PEG Linker.
V82975	Thalidomide-NH-PEG4-COOH	2412056-48-3	Thalidomide-NH-PEG4-COOH is an E3 ligase (e.g. CRBN) ligand-linker conjugate that may be utilized to prepare dCBP-1.
V82668	Thalidomide-NH-PEG4-Ms	2140807-24-3	Thalidomide-NH-PEG4-Ms is an E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker.
V82646	Thalidomide-O-amide-C5-NH2	2360527-40-6	Thalidomide-O-amide-C5-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82635	Thalidomide-O-amide-C5-NH2 TFA	2748161-83-1	Thalidomide-O-amide-C5-NH2 TFA is a synthetic E3 ligase (e..g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82945	Thalidomide-O-amido-C3-COOH (Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15)	2308035-51-8	Thalidomide-O-amido-C3-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82647	Thalidomide-O-amido-C3-NH2 (Cereblon Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 52)	2022182-57-4	Thalidomide-O-amido-C3-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V83019	Thalidomide-O-amido-C3-PEG3-C1-NH2	1799711-29-7	Thalidomide-O-amido-C3-PEG3-C1-NH2 is a ligand (for E3 ligase )-linker conjugate containing a Thalidomide-based cereblon ligand and a 3-unit PEG linker.
V82644	Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11; E3 Ligase Ligand-Linker Conjugates 25)	1950635-13-8	Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, may be utilized to prepare PROTAC molecules.
V82649	Thalidomide-O-amido-C8-NH2 hydrochloride	2415263-07-7	Thalidomide-O-amido-C8-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, may be utilized to prepare PROTAC molecules.
V82751	Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc	1799711-31-1	Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate.
V82651	Thalidomide-O-amido-PEG-C2-NH2	2022182-59-6	Thalidomide-O-amido-PEG-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.