PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82657 | Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 (Cereblon Ligand-Linker Conjugates 12; E3 Ligase Ligand-Linker Conjugates 23) | 2435572-48-6 | Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a ligand (for E3 ligase )-linker conjugate containing a Thalidomide-based cereblon ligand and 1 linker. |
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V82992 | Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 12 TFA; E3 Ligase Ligand-Linker Conjugates 23 TFA) | 2435572-49-7 | Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a ligand (for E3 ligase )-linker conjugate containing a Thalidomide-based cereblon ligand and a 3-unit PEG linker. |
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V82661 | Thalidomide-O-amido-PEG4-C2-NH2 | 1957236-22-4 | Thalidomide-O-amido-PEG4-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
|
V82998 | Thalidomide-O-C2-acid | 2369068-42-6 | Thalidomide-O-C2-acid is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V82642 | Thalidomide-O-C3-acid | 2169266-64-0 | Thalidomide-O-C3-acid is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82666 | Thalidomide-O-C4-COOH | 2169266-67-3 | Thalidomide-O-C4-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82688 | Thalidomide-O-C4-NH2 | 1957235-96-9 | Thalidomide-O-C4-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
|
V82952 | Thalidomide-O-C5-acid | 2087490-48-8 | Thalidomide-O-C5-acid is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V82990 | Thalidomide-O-C6-COOH | 2169266-69-5 | Thalidomide-O-C6-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V82663 | Thalidomide-O-C7-acid | 2169266-70-8 | Thalidomide-O-C7-acid is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82997 | Thalidomide-O-C8-Boc | 2225148-52-5 | Thalidomide-O-C8-Boc is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. |
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V82951 | Thalidomide-O-C8-COOH | 2225148-51-4 | Thalidomide-O-C8-COOH is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN proteins. |
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V82894 | Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | Thalidomide-O-PEG4-amine HCl is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82664 | Thalidomide-PEG2-C2-NH2 (Thalidomide-NH-PEG2-C2-NH2) | 2093416-32-9 | Thalidomide-PEG2-C2-NH2 is a ligand (for E3 ligase )-linker conjugate containing a Thalidomide-based cereblon ligand and 2 Polyethylene glycol (PEG) units linker. |
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V82654 | Thalidomide-PEG2-NH2 | 1957235-94-7 | Thalidomide-PEG2-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V83000 | Thalidomide-PEG2-NH2 hydrochloride | 2891597-17-2 | Thalidomide-PEG2-NH2 HCl is a ligand (for E3 ligase)-linker conjugates, containing a cereblon ligand based on Thalidomide (Thalidomide) and a linker. |
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V82962 | Thalidomide-PEG3-COOH | 2682112-08-7 | Thalidomide-PEG3-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V82658 | Thalidomide-PEG3-NH2 | 1957236-10-0 | Thalidomide-PEG3-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V83022 | Thalidomide-PEG4-COOH | 2828438-28-2 | Thalidomide-PEG4-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
|
V83016 | Thalidomide-PEG4-NH2 hydrochloride | 2387510-82-7 | Thalidomide-PEG4-NH2 HCl is a ligand (for E3 ligase )-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker. |
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