PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82632 | Thalidomide-PEG4-Propargyl | 2098799-77-8 | Thalidomide-PEG4-Propargyl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker. |
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V83017 | Thalidomide-PEG5-COOH | 2688100-28-7 | Thalidomide-PEG5-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82628 | Thalidomide-PEG5-NH2 | 2460263-40-3 | Thalidomide-PEG5-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V83003 | Thalidomide-PEG5-NH2 hydrochloride | 2703775-06-6 | Thalidomide-PEG5-NH2 HCl is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82779 | Thalidomide-Piperazine 5-fluoride | 2222114-22-7 | Thalidomide-Piperazine 5-fluoride is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82948 | Thalidomide-piperazine-Boc | 2222114-64-7 | Thalidomide-piperazine-Boc is an intermediate useful in the preparation /synthesis of BCL6 PROTAC. |
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V82931 | Thalidomide-Piperazine-PEG1-COOH | 2731007-11-5 | Thalidomide-Piperazine-PEG1-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V83018 | Thalidomide-Piperazine-PEG1-NH2 | 2357111-29-4 | Thalidomide-Piperazine-PEG1-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82960 | Thalidomide-Piperazine-PEG2-COOH | 2797430-20-5 | Thalidomide-Piperazine-PEG2-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V83025 | Thalidomide-Piperazine-PEG2-NH2 | 2357110-14-4 | Thalidomide-Piperazine-PEG2-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82955 | Thalidomide-Piperazine-PEG3-COOH | 2797619-63-5 | Thalidomide-Piperazine-PEG3-COOH is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82656 | Thalidomide-Piperazine-PEG3-NH2 | 2357113-68-7 | Thalidomide-Piperazine-PEG3-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V82660 | Thalidomide-Piperazine-Piperidine | 2229716-11-2 | Thalidomide-Piperazine-Piperidine is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker. |
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V83023 | Thalidomide-Propargyne-PEG1-COOH | 2828438-36-2 | Thalidomide-Propargyne-PEG1-COOH is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker. |
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V83026 | Thalidomide-Propargyne-PEG2-COOH | 2797619-65-7 | Thalidomide-Propargyne-PEG2-COOH is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker. |
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V83024 | Thalidomide-Propargyne-PEG3-COOH | 2797649-54-6 | Thalidomide-Propargyne-PEG3-COOH is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker. |
|
V82743 | Thiol-C9-PEG4-acid | 716339-41-2 | Thiol-C9-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V81577 | Thiol-C9-PEG5-acid | Thiol-C9-PEG5-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V80302 | Thiol-PEG-COOH (MW 5000) | Thiol-PEG-COOH (MW 5000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. | |
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V80297 | Thiol-PEG4-amide-NH2 | Thiol-PEG4-amide-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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