PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V80229	THP-C1-PEG5		THP-C1-PEG5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V80037	THP-C4-PEG4		THP-C4-PEG4 is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82694	THP-PEG1-alcohol	2162-31-4	THP-PEG1-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80532	THP-PEG1-Boc		THP-PEG1-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V81578	THP-PEG10-Boc		THP-PEG10-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78113	THP-PEG10-C2-Boc		THP-PEG10-C2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78114	THP-PEG11-THP		THP-PEG11-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V78335	THP-PEG12-alcohol		THP-PEG12-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V81579	THP-PEG12-THP		THP-PEG12-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V81580	THP-PEG13-Boc		THP-PEG13-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78144	THP-PEG13-OH		THP-PEG13-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V81581	THP-PEG16-alcohol		THP-PEG16-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V81582	THP-PEG16-THP		THP-PEG16-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V80536	THP-PEG2-Mal		THP-PEG2-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80531	THP-PEG2-methyl propionate		THP-PEG2-methyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V81583	THP-PEG24-THP		THP-PEG24-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V79900	THP-PEG4-Boc		THP-PEG4-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V80449	THP-PEG4-C1-OH		THP-PEG4-C1-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V81584	THP-PEG6-C2-Boc		THP-PEG6-C2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82715	THP-PEG7-alcohol	873110-21-5	THP-PEG7-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.