PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V78699	THP-PEG8-Boc		THP-PEG8-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78700	THP-PEG8-THP		THP-PEG8-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V82858	THP-PEG9-OH	669556-83-6	THP-PEG9-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82935	Tos-O-C4-NH-Boc	180851-50-7	Tos-O-C4-NH-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl ether category.
V80334	Tos-PEG1-O-CH2COOH (PROTAC Linker 28)		Tos-PEG1-O-CH2COOH (PROTAC (PROteolysis TArgeting Chimera) linker 28) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82677	Tos-PEG13-Boc	2820397-84-8	Tos-PEG13-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V81601	Tos-PEG14-OH		Tos-PEG14-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82711	Tos-PEG2-NH2 (PROTAC Linker 27)	1246286-33-8	Tos-PEG2-NH2 (PROTAC (PROteolysis TArgeting Chimera) linker 27) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82756	Tos-PEG2-OH	118591-58-5	Tos-PEG2-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V16609	Tos-PEG2-t-butyl ester	1309666-78-1	Tos-PEG2-t-butyl ester is a PEG analogue containing a t-butyl ester and a tosyl group.
V16612	Tos-PEG3-t-butyl ester	850090-13-0	Tos-PEG3-t-butyl ester is a PEG analogue containing a t-butyl ester and a tosyl group.
V16616	Tos-PEG4-t-butyl ester	217817-01-1	Tos-PEG4-t-butyl ester is a PEG analogue containing a t-butyl ester and a tosyl group.
V16619	Tos-PEG5-t-butyl ester	581065-94-3	Tos-PEG5-t-butyl ester is a PEG analogue containing a t-butyl ester and a tosyl group.
V82875	Tri(Amino-PEG3-amide)-amine	2523025-40-1	Tri(Amino-PEG3-amide)-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77909	Tri(Amino-PEG3-amide)-amine TFA		Tri(Amino-PEG3-amide)-amine TFA is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V81610	Tri(Amino-PEG4-amide)-amine TFA		Tri(Amino-PEG4-amide)-amine TFA is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V77880	VES-POFP		VES-POFP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82868	VH032 analogue-2	1448189-66-9	VH032 analogue-2 is a VH032 analogue that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins.
V82810	VH032-C3-Boc	2827750-25-2	VH032-C3-Boc is a Boc-modified VH032 that can serve as a ligand for VHL and recruit von Hippel-Lindau (VHL) protein.
V82687	VH032-CH2-Boc	2827750-24-1	VH032-CH2-Boc is Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein.