PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V77919	Amino-PEG2-CH2CH2-SH hydrochloride		Amino-PEG2-CH2CH2-SH (HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V8373	Amino-PEG2-t-butyl ester	756525-95-8	Amino-PEG2-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.
V82850	Amino-PEG24-acid	2563873-76-5	Amino-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V11104	Amino-PEG3-acid	784105-33-5	Amino-PEG3-acid is a PEG analogue containing an amino group with a terminal carboxylic acid.
V5760	Amino-PEG3-alcohol	6338-55-2	Amino-PEG3-alcohol is a PEG analogue containing an amino group with a hydroxyl group.
V11108	Amino-PEG3-t-butyl ester	252881-74-6	Amino-PEG3-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.
V11109	Amino-PEG4-acid	663921-15-1	Amino-PEG4-acid is a PEG analogue containing an amino group with a terminal carboxylic acid.
V11110	Amino-PEG4-alcohol	86770-74-3	Amino-PEG4-alcohol is a PEG analogue containing an amino group with a hydroxyl group.
V77922	Amino-PEG4-C2-SH hydrochloride		Amino-PEG4-C2-SH HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V5620	Amino-PEG4-t-butyl ester	581065-95-4	Amino-PEG4-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.
V8602	Amino-PEG5-alcohol	34188-11-9	Amino-PEG5-alcohol is a PEG analogue containing an amino group with a hydroxyl group.
V7830	Amino-PEG6-alcohol	39160-70-8	Amino-PEG6-alcohol is a PEG analogue containing an amino group with a hydroxyl group.
V77923	Amino-PEG7-C2-SH hydrochloride		Amino-PEG7-C2-SH HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82771	Aminooxy-PEG8-acid	2055269-60-6	Aminooxy-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77231	ATP-PEG8-Biotin		ATP-PEG8-Biotin is a PEG-like linker that binds ATP.
V82774	AZD9496 deacrylic acid phenol	2173404-70-9	AZD9496 deacrylic acid phenol is a fragment of the PROTAC ER Degrader-4 target protein ligand.
V82885	Azide-PEG3-Desthiobiotin	1426828-06-9	Azide-PEG3-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V80255	Azido-C1-PEG4-C3-NH2		Azido-C1-PEG4-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82919	Azido-PEG1	1517-05-1	Azido-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82742	Azido-PEG10-azide	1421783-42-7	Azido-PEG10-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.