PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V12183	Azido-PEG3-acid	1056024-94-2	Azido-PEG3-acid (N3-PEG3-CH2CH2COOH) is a novel and potent PEG (polyethyleneglycol) analogueused as a PROTAC linker for the synthesis of BI-3663, BI-4216 and BI-0319.
V10172	Azido-PEG3-alcohol	86520-52-7	Azido-PEG3-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.
V82793	Azido-PEG3-aldehyde	1807530-10-4	Azido-PEG3-aldehyde is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V12184	Azido-PEG3-amine	134179-38-7	Azido-PEG3-amine is a PEG analogue containing an amino group with an azide group.
V80112	Azido-PEG3-amino-OPSS		Azido-PEG3-amino-OPSS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78314	Azido-PEG36-NHSester		Azido-PEG36-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V12194	Azido-PEG4-acid	1257063-35-6	Azido-PEG4-acid is a PEG analoguecontaining an azide group and is used as aPROTAC linker for the synthesis of Rucaparib-based PARP PROTAC degraders.
V78316	Azido-PEG4-acyl chloride		Azido-PEG4-acyl chloride is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V10173	Azido-PEG4-alcohol	86770-67-4	Azido-PEG4-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.
V12204	Azido-PEG4-amine	951671-92-4	Azido-PEG4-amine is a PEG analogue containing an amino group with an azide group.
V80195	Azido-PEG4-formylhydrazine-Boc		Azido-PEG4-formylhydrazine-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82670	Azido-PEG4-propargyl	1192590-91-2	Azido-PEG4-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82907	Azido-PEG4-Thiol	2720615-82-5	Azido-PEG4-Thiol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82798	Azido-PEG4-THP	145927-74-8	Azido-PEG4-THP is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V6771	Azido-PEG5-alcohol	86770-68-5	Azido-PEG5-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.
V10176	Azido-PEG6-alcohol	86770-69-6	Azido-PEG6-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.
V83006	Azido-PEG6-CH2COOH	880129-82-8	Azido-PEG6-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82876	Azido-PEG6-MS	352439-38-4	Azido-PEG6-MS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V80167	Azido-PEG6-THP		Azido-PEG6-THP is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V80039	Azido-PEG7-acid		Azido-PEG7-acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.