PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V79510	Azido-PEG7-NHSester		Azido-PEG7-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78319	Azido-PEG7-PFP ester		Azido-PEG7-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82818	Azido-PEG8-azide	361543-07-9	Azido-PEG8-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82678	Azido-PEG8-C-Boc	1984776-39-7	Azido-PEG8-C-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V82729	Azido-PEG8-NHBoc	2231845-12-6	Azido-PEG8-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82805	Azido-PEG8-propargyl	1196733-06-8	Azido-PEG8-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78320	Azido-PEG8-THP		Azido-PEG8-THP is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V78321	Azido-PEG9-CH2COOH		Azido-PEG9-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82824	BDP FL-PEG5-acid	2093197-98-7	BDP FL-PEG5-acid is a BDP FL acid linker containing a hydrophilic PEG spacer arm.
V82767	Benzyl-PEG1-Ms	58841-52-4	Benzyl-PEG1-Ms is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82769	Benzyl-PEG10-alcohol	908258-44-6	Benzyl-PEG10-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78380	Benzyl-PEG10-Ots		Benzyl-PEG10-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V78115	Benzyl-PEG10-t-butyl ester		Benzyl-PEG10-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78116	Benzyl-PEG10-THP		Benzyl-PEG10-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78341	Benzyl-PEG11-alcohol		Benzyl-PEG11-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77911	Benzyl-PEG11-Boc		Benzyl-PEG11-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78382	Benzyl-PEG11-MS		Benzyl-PEG11-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78383	Benzyl-PEG12-MS		Benzyl-PEG12-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77885	Benzyl-PEG12-Ots		Benzyl-PEG12-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V78384	Benzyl-PEG13-alcohol		Benzyl-PEG13-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.