PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V78394	Benzyl-PEG25-amine		Benzyl-PEG25-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82681	Benzyl-PEG3-methyl ester	127457-61-8	Benzyl-PEG3-methyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82833	Benzyl-PEG3-MS	702701-70-0	Benzyl-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78396	Benzyl-PEG36-alcohol		Benzyl-PEG36-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78400	Benzyl-PEG4-acyl chloride		Benzyl-PEG4-acyl chloride is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82689	Benzyl-PEG4-Boc	2484091-04-3	Benzyl-PEG4-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78398	Benzyl-PEG45-alcohol		Benzyl-PEG45-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82755	Benzyl-PEG5-THP	230620-74-3	Benzyl-PEG5-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79838	Benzyl-PEG6-acid		Benzyl-PEG6-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82828	Benzyl-PEG6-azide	86770-73-2	Benzyl-PEG6-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82754	Benzyl-PEG6-bromide	1449202-44-1	Benzyl-PEG6-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82794	Benzyl-PEG6-NHBoc	2148295-93-4	Benzyl-PEG6-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82733	Benzyl-PEG6-Ots	129086-11-9	Benzyl-PEG6-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category.
V79311	Benzyl-PEG7-acid		Benzyl-PEG7-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82838	Benzyl-PEG7-azide	868594-42-7	Benzyl-PEG7-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V79516	Benzyl-PEG7-bromide		Benzyl-PEG7-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79309	Benzyl-PEG7-MS		Benzyl-PEG7-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78401	Benzyl-PEG7-NHBoc		Benzyl-PEG7-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78424	Benzyl-PEG7-Ots		Benzyl-PEG7-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category.
V78701	Benzyl-PEG7-t-butyl ester		Benzyl-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.