PROTACs

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.

PROTACs related products

Cat No.	Product Name	CAS No.	Product Description
V83031	Boc-NH-PEG7-acetic acid	141282-29-3	Boc-NH-PEG7-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V3581	BRD4 degrader AT1	2098836-45-2	BRD4 degrader AT1 is a novel, potent and highly selectivePROTAC-based BRD4degrader (Kd= 44 nM for Brd4BD2in cells) with anticancer activity.
V3439	BSJ-03-123	2361493-16-3	BSJ-03-123 is a novel, potentcyclin-dependent kinase 6 (CDK6)-selective small-molecule degrader (PROTAC: proteolysis targeting chimera).
V77183	BSJ-03-204triTFA		BSJ-03-204 triTFA is a PROTAC linked by Cereblon ligand and CDK ligand.
V2485	BSJ-4-116	2519823-34-6	BSJ-4-116 is a PROTAC protein degrader linked by Cereblon ligand and CDK ligand.
V78571	BT-PROTAC	3032848-64-6	BT-PROTAC is a bioorthogonally activated prodrug.
V83053	Bz-Ala-Arg	71448-11-8	Bz-Ala-Arg is a dipeptide.
V93584	c-Kit-IN-7	2941026-35-1	c-Kit-IN-7 (Compound 104) is a potent inhibitor of c-Kit with IC50 less than or equal to 10 nM.
V70083	C004019	2417159-57-8	C004019 is a small molecule PROTAC.
V78617	CaMKIIα-PHOTAC		CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).
V88885	CARM1 degrader-1 hydrochloride		CARM1 degrader-1 hydrochloride is the hydrochloride form of CARM1 degrader-1.
V88865	CBPD-409		CBPD-409 is an orally available CBP/p300 degrader with a DC50 of 0.2–0.4 nM.
V83030	Cbz-PEG2-bromide	2100283-00-7	Cbz-PEG2-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V77160	CCT367766 formic		CCT367766 formic is a potent orally bioactive protein, a third-generation heterofunctional and Cereblon ligand-based pirin-targeted protein degradation probe (PDP, or PROTAC) that can reduce pirin protein expression at low concentrations.
V101101	CDK2 degrader 2	3030271-16-7	CDK2 Degrader 2 is a PROTAC-type CDK2 degrader, whose CDK2 binding moiety (CBM) is ubiquitinated after binding to CDK2 protein, thereby degrading CDK2 through the ubiquitin-proteasome pathway (UPP).
V37524	CDK9 Antagonist-1		CDK9 Antagonist-1
V97287	CEP1347-VHL-02		CEP1347-VHL-02 is a PROTAC targeting MLK3, which consists of PROTAC target protein ligand CEP-1347 (red part), E3 ubiquitin ligase ligand (S,R,S)-AHPC-Me (blue part) and PROTAC Linker Amino-PEG3-CH2COOH (black part). The target protein ligand activity control is CEP-1347-acid, and the E3 ubiquitin ligase ligand + Linker conjugate is (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2.
V17301	CM11 (Homo-PROTAC)	2244684-49-7	Homo-PROTAC pVHL30 degrader 1 is an effective PROTAC-based pVHL30 degrader.
V78867	CP-07		CP-07 is a potent and specific PROTAACCDK9 degrader (DC50= 43 nM).
V104423	CPD-10	3055471-57-0	CPD-10 is a potent CCND1 and CDK4 PROTAC degrader.