Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V37558 | E3 ligase Ligand 1 dihydrochloride | E3 ligase Ligand 1 dihydrochloride is a compound used in PROTAC technology to recruit E18 ligase. | ||
V37557 | E3 ligase Ligand 13 | E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand. | ||
V37536 | E3 ligase Ligand-Linker Conjugates 15 | E3 ligase Ligand-Linker Conjugates 15comprises of a cereblon ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37537 | E3 Ligase Ligand-Linker Conjugates 23 TFA | E3 Ligase Ligand-Linker Conjugates 23 TFAcomprises of a cereblon ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37529 | E3 ligase Ligand-Linker Conjugates 30 TFA | E3 ligase Ligand-Linker Conjugates 30 TFAcomprises of a cereblon ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37559 | E3 ligase Ligand-Linker Conjugates 32 hydrochloride | E3 ligase Ligand-Linker Conjugates 32 hydrochloride is a lenalidomide-based ligand used in the recruitment of CRBN protein. | ||
V37531 | E3 ligase Ligand-Linker Conjugates 33 | E3 ligase Ligand-Linker Conjugates 33comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37535 | E3 ligase Ligand-Linker Conjugates 35 Hydrochlride | E3 ligase Ligand-Linker Conjugates 35 Hydrochlridecomprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37527 | E3 ligase Ligand-Linker Conjugates 37 Hydrochloride | E3 ligase Ligand-Linker Conjugates 37 Hydrochloridecomprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37534 | E3 ligase Ligand-Linker Conjugates 42 | E3 ligase Ligand-Linker Conjugates 42comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37525 | E3 ligase Ligand-Linker Conjugates 43 | E3 ligase Ligand-Linker Conjugates 43comprises of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37533 | E3 ligase Ligand-Linker Conjugates 44 | E3 ligase Ligand-Linker Conjugates 44comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37530 | E3 ligase Ligand-Linker Conjugates 45 | E3 ligase Ligand-Linker Conjugates 45comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37532 | E3 ligase Ligand-Linker Conjugates 46 | E3 ligase Ligand-Linker Conjugates 46comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37528 | E3 ligase Ligand-Linker Conjugates 47 | E3 ligase Ligand-Linker Conjugates 47comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V37526 | E3 ligase Ligand-Linker Conjugates 48 | E3 ligase Ligand-Linker Conjugates 48comprises of a MDM2 ligand for the E3 ubiquitin ligase and a PROTAC linker. | ||
V31331 | ERD-308 | 2320561-35-9 | ERD-308 (ERD308) is a highly potent PROTAC degrader of estrogen receptor (ER) with the potential for treating ER positive breast cancer treatment (DC50: 0.17 nM (ER in MCF-7 cells)). | |
V67694 | ERD-3111 | 2832865-25-3 | ERD-3111 (Compound 44) is an orally bioactive PROTAC ERα degrader (DC50= 0.5 nM). | |
V83042 | Ethyl acetate-PEG1 | 2093-20-1 | Ethyl acetate-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V83034 | FmocNH-PEG3-CH2CH2NH2 hydrochloride | 906079-91-2 | FmocNH-PEG3-CH2CH2NH2 (HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |