PROTACs

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.

PROTACs related products

Cat No.	Product Name	CAS No.	Product Description
V37533	E3 ligase Ligand-Linker Conjugates 44		E3 ligase Ligand-Linker Conjugates 44comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37536	E3 ligase Ligand-Linker Conjugates 15		E3 ligase Ligand-Linker Conjugates 15comprises of a cereblon ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37559	E3 ligase Ligand-Linker Conjugates 32 hydrochloride		E3 ligase Ligand-Linker Conjugates 32 hydrochloride is a lenalidomide-based ligand used in the recruitment of CRBN protein.
V37531	E3 ligase Ligand-Linker Conjugates 33		E3 ligase Ligand-Linker Conjugates 33comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37534	E3 ligase Ligand-Linker Conjugates 42		E3 ligase Ligand-Linker Conjugates 42comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37525	E3 ligase Ligand-Linker Conjugates 43		E3 ligase Ligand-Linker Conjugates 43comprises of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37530	E3 ligase Ligand-Linker Conjugates 45		E3 ligase Ligand-Linker Conjugates 45comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37532	E3 ligase Ligand-Linker Conjugates 46		E3 ligase Ligand-Linker Conjugates 46comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37528	E3 ligase Ligand-Linker Conjugates 47		E3 ligase Ligand-Linker Conjugates 47comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37526	E3 ligase Ligand-Linker Conjugates 48		E3 ligase Ligand-Linker Conjugates 48comprises of a MDM2 ligand for the E3 ubiquitin ligase and a PROTAC linker.
V37557	E3 ligase Ligand 13		E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand.
V37558	E3 ligase Ligand 1 dihydrochloride		E3 ligase Ligand 1 dihydrochloride is a compound used in PROTAC technology to recruit E18 ligase.
V104015	ERD-12310A		ERD-12310A is a PROTAC targeting estrogen receptor α (ERα) with an ED50 value of 47 pM.
V104626	ERD-1233		ERD-1233 is a potent and orally bioavailable estrogen receptor PROTAC degrader with a DC50 of 0.9 nM.
V31331	ERD-308	2320561-35-9	ERD-308 (ERD308) is a highly potent PROTAC degrader of estrogen receptor (ER) with the potential for treating ER positive breast cancer treatment (DC50: 0.17 nM (ER in MCF-7 cells)).
V67694	ERD-3111	2832865-25-3	ERD-3111 (Compound 44) is an orally bioactive PROTAC ERα degrader (DC50= 0.5 nM).
V83042	Ethyl acetate-PEG1	2093-20-1	Ethyl acetate-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V105327	F1-RIBOTAC	3019907-96-8	F1-RIBOTAC is a ribonuclease targeting chimera (RIBOTAC).
V83034	FmocNH-PEG3-CH2CH2NH2 hydrochloride	906079-91-2	FmocNH-PEG3-CH2CH2NH2 (HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V101161	FOSL1 degrader 1		FOSL1 degrader 1 (4) is a T-5224-PROTAC that effectively degrades FOSL1 (AP-1), thereby inhibiting the expression of HNSCC cancer stem cell genes.