PROTACs

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PROTACs

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.

PROTACs related products

Cat No.	Product Name	CAS No.	Product Description
V83035	PROTAC Her3 Degrader-8	2103331-95-7	PROTAC Her3 Degrader-8 (Compound PP2) is a PROTAC that can degrade Her3 proteins in in vitro experiments and cell experiments and may be utilized to study diseases regulated by HER family proteins.
V37561	PROTAC IAP binding moiety 1		PROTAC IAP binding moiety 1 is a warhead targeting IAP, used in PROTAC technology.
V37562	PROTAC IAP binding moiety 2		PROTAC IAP binding moiety 2 is a warhead targeting IAP, used in PROTAC technology.
V76592	PROTAC IRAK3 degrade-1 formic		PROTAC IRAK3 degrade-1 (compound 23) formic is a potent and specific IRAK3 degrader (IC50 = 5 nM).
V75061	PROTAC IRAK4 degrader-3	2374122-43-5	PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC.
V75068	PROTAC IRAK4 degrader-4	2360528-45-4	PROTAC IRAK4 degrader-4 is a Cereblon-based IRAK4 degrader PROTAC.
V75071	PROTAC IRAK4 degrader-5	2360530-61-4	PROTAC IRAK4 Degrader-5 is an IRAK4 degrader based on Cereblon.
V75069	PROTAC IRAK4 degrader-6	2360530-72-7	PROTAC IRAK4 degrader-6 is a Cereblon-based IRAK4 degrader PROTAC.
V76591	PROTAC KRAS G12C degrader-1		PROTAC KRAS G12C degrader-1 is a KRASG12C PROTAC degrader based on Cereblon.
V69816	PROTAC MEK1 Degrader-1	2671004-41-2	PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with pIC50 of 7.0.
V81233	PROTAC MLKL Degrader-1		PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC targeted degrader of MLKL with Dmax >90%.
V81234	PROTAC NSD3 degrader-1		PROTAC NSD3 degrader-1 (compound 56) is a PROTAC that targets the nuclear receptor-binding SET domain protein NSD3.
V37546	PROTAC PARP1 degrader	2369022-68-2	PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand.
V74142	PROTAC RAF degrader 1	2413035-41-1	PROTAC RAF degrader 1 (compound 512) is a PROTAC RAF degrader.
V81235	PROTAC SOS1 degrader-4		PROTAC SOS1 degrader-4 (compound 10) is a potent SOS1 degrader.
V69154	PROTAC STAT3 degrader-2	2429877-78-9	PROTAC STAT3 degrader-2 is a selective PROTAC degrader of STAT3 protein with DC50 of 3.54 μM in Molm-16 cells.
V77698	PROTAC TG2 degrader-1		PROTAC TG2 degrader-1 (Compound 11) is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM.
V81236	PROTAC TG2 degrader-2		PROTAC TG2 degrader-2 (compound 7) is a selective and competitive degrader targeting Transglutaminase 2 (TG2) with a Kd > 100 μM.
V70183	PROTAC α-synuclein degrader 3	2412273-77-7	PROTAC α-synuclein degrader 3 (compound 5) is a potent and specific PROTAC α-synuclein degrader.
V70184	PROTAC α-synuclein degrader 5	2781922-42-5	PROTAC α-synuclein degrader 5 is a selective small molecule degrader (PROTAC) for α-synuclein aggregates, with DC50 of 7.51 μM and a maximum degradation rate of Dmax of 89%.