A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79395 | Anti-inflammatory agent 60 | Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production with IC50 of 12.95 μM. | |
|
V88157 | Antitumor agent-171 | 3003004-76-7 | Antitumor agent-171 (Compound 35) is an inhibitor of β-catenin/BCL9 interaction with IC50 of 1.61 μM. |
|
V88158 | Antitumor agent-172 | 3027905-74-1 | Antitumor agent-172 (Compound 28) is an inhibitor of β-catenin/BCL9 interaction with IC50 of 3.92 μM. |
|
V88138 | aStAx-35R | 1418863-17-8 | aStAx-35R is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. |
|
V88137 | aStAx-35R TFA | aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. | |
|
V98486 | BC21 | 691005-38-6 | BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor, which effectively inhibits the binding of β-catenin to Tcf4-derived peptides with IC50 of 5 μM. |
|
V79819 | BMP agonist 1 | BMP agonist 1 (compound 2 b) is a small molecule agonist of bone morphogenetic protein (BMP). | |
|
V80070 | CDK8-IN-11 hydrochloride | CDK8-IN-11 HCl is a potent and specific inhibitor of CDK8 with IC50 of 46 nM. | |
|
V88153 | CGK012 | 2044497-76-7 | CKG012 is an inhibitor of the Wnt/βcatenin signaling pathway. |
|
V86081 | E722-2648 | 931963-55-2 | |
|
V78739 | hCA/Wnt/β-catenin-IN-1 | hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor (blocker/antagonist) of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). | |
|
V80395 | IR-251 | IR-251 is a mitochondria-targeted near-infrared fluorescent probe. | |
|
V67517 | KY1022 | 1029721-36-5 | KY1022 is a small molecule that destabilizes Ras by targeting the Wnt/β-catenin pathway. |
|
V51021 | Miclxin (DS-37262926) | 2494198-61-5 | Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involved in Wnt signaling. |
|
V67510 | Nefopam-d3 hydrochloride (Fenazoxine-d3 (hydrochloride)) | 1346603-30-2 | Nefopam-d3 ( HCl) is the deuterated form of Nefopam HCl. |
|
V88156 | NF764 | NF764 is a potent β-catenin (CTNNB1) degrader. | |
|
V80955 | NLS-StAx-h TFA | NLS-StAx-h TFA is a selective, cell-permeable (penetrable), immobilized peptide inhibitor of Wnt signaling with IC50 of 1.4 μM. | |
|
V67503 | NRX-103094 | 2763260-36-0 | NRX-103094 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/Ser37 β-catenin and β-TrCP with EC50 of 62 nM and a Kd of 0.6 nM. |
|
V67506 | NRX-103095 | 2763260-38-2 | NRX-103095 is an enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP. |
|
V67505 | NRX-252114 | 2763260-39-3 | NRX-252114 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin and β-TrCP with EC50 of 6.5 nM and a Kd of 0.4 nM. |
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