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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine V55825 2'-Deoxy-2'-iodouridine; 2'-Iodo-2'-deoxyuridine 4753-03-1 2'-Deoxy-2'-iodouridine; 2'-Iodo-2'-deoxyuridine is an analogue of purine nucleoside.
2′-Deoxy-2-hydrazinyladenosine V55872 2′-Deoxy-2-hydrazinyladenosine 1000296-26-3 2′-Deoxy-2-hydrazinyladenosine is an analogue of purine nucleoside.
2′-Deoxy-2-iodoadenosine V75581 2′-Deoxy-2-iodoadenosine 118706-49-3 2′-Deoxy-2-iodoadenosine is an analogue of purine nucleoside.
2′-Deoxy-2-thiouridine V75589 2′-Deoxy-2-thiouridine 35059-12-2 2′-Deoxy-2-thiouridine is an analogue of purine nucleoside.
2’-Deoxy-3’,2-anhydrouridine V55903 2'-Deoxy-3',2-anhydrouridine 26922-44-1 2'-Deoxy-3',2-anhydrouridine is an analogue of purine nucleoside.
2'-Deoxy-5'-O-DMT-5-methylcytidine V55340 2'-Deoxy-5'-O-DMT-5-methylcytidine 176755-83-2 2'-Deoxy-5'-O-DMT-5-methylcytidine is a cytosine nucleoside analogue.
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine V55494 2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 176755-86-5 2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine is a cytosine nucleoside analogue.
2’-Deoxy-5,N4,N4-trimethylcytidine V55822 2'-Deoxy-5,N4,N4-trimethylcytidine 25406-45-5 2'-Deoxy-5,N4,N4-trimethylcytidine is an analogue of purine nucleoside.
2'-Deoxy-5,N4-dimethylcytidine V75610 2'-Deoxy-5,N4-dimethylcytidine 25406-44-4 2'-Deoxy-5,N4-dimethylcytidine is an analogue of purine nucleoside.
2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium V55413 2'-Deoxy-5-Fluorouridine 5'-phosphate triethylammonium 134-46-3 2'-Deoxy-5-Fluorouridine 5'-phosphate (triethylammonium) is an analogue of purine nucleoside.
2′-Deoxy-5-methylisocytidine V55907 2′-Deoxy-5-methylisocytidine 19316-88-2 2′-Deoxy-5-methylisocytidine is an analogue of purine nucleoside.
2′-Deoxy-6-O-methylinosine V55621 2′-Deoxy-6-O-methylinosine 37109-88-9 2′-Deoxy-6-O-methylinosine is an analogue of purine nucleoside.
2′-Deoxy-6-thioinosine V56014 2′-Deoxy-6-thioinosine 2239-64-7 2′-Deoxy-6-thioinosine is an analogue of purine nucleoside.
2′-Deoxy-8-(methylthio)adenosine V75631 2′-Deoxy-8-(methylthio)adenosine 29836-02-0 2′-Deoxy-8-(methylthio)adenosine is an analogue of purine nucleoside.
2′-Deoxy-8-(phenylmethoxy)guanosine V55891 2′-Deoxy-8-(phenylmethoxy)guanosine 96964-90-8 2′-Deoxy-8-(phenylmethoxy)guanosine is an analogue of purine nucleoside.
2'-Deoxy-8-methylamino-adenosine V55703 2'-Deoxy-8-methylamino-adenosine 13389-10-1 2'-Deoxy-8-methylamino-adenosine is an analogue of purine nucleoside.
2'-Deoxy-8-methylthioguanosine V55995 2'-Deoxy-8-methylthioguanosine 157946-92-4 2'-Deoxy-8-methylthioguanosine is an analogue of purine nucleoside.
2'-Deoxy-L-guanosine V52512 2'-Deoxy-L-guanosine 22837-44-1 2'-Deoxy-L-guanosine selectively inhibits D-thymidine phosphorylation catalyzed by HSV 1 thymidine kinase.
2′-Deoxy-N-(2-furanylmethyl)guanosine V55958 2′-Deoxy-N-(2-furanylmethyl)guanosine 1227069-12-6 2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanine nucleoside analog.
2′-Deoxy-N-methylguanosine V55840 2′-Deoxy-N-methylguanosine 19916-77-9 2'-Deoxy-N2-methylguanosine, DNA adduct is an analogue of purine nucleoside.
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