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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
2'-F-Bz-dC Phosphoramidite V53386 2'-F-Bz-dC Phosphoramidite 161442-19-9 2'-F-Bz-dC Phosphoramidite may be utilized in the synthesis/preparation of oligoribonucleotides such as DNA and RNA.
2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite V55658 2'-Fluoro-2'-deoxy-ara-A(Bz)-3'-phosphoramidite 329187-86-2 2'-Fluoro-2'-deoxy-ara-A(Bz)-3'-phosphoramidite is an adenine nucleoside analog.
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite V55679 2'-Fluoro-2'-deoxy-ara-C(Bz)-3'-phosphoramidite 1404463-12-2 2'-Fluoro-2'-deoxy-ara-C(Bz)-3'-phosphoramidite is a cytosine nucleoside analog.
2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite V55989 2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite 1190089-70-3 2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a uridine analog.
2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine V55981 2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine 144924-81-2 2'-Fluoro-2'-deoxy-N6,N6-dimethylarabinoadenosine is an analogue of purine nucleoside.
2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine V55806 2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine 126502-12-3 2'-Fluoro-2'-deoxy-N6-methylarabinoadenosine is an analogue of purine nucleoside.
2'-Fluoro-2-thio-2'-dU-3'-phosphoramidite V75621 2'-Fluoro-2-thio-2'-dU-3'-phosphoramidite 152753-94-1 2'-Fluoro-2-thio-2'-dU-3'-phosphoramidite is an analogue of purine nucleoside.
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite V51319 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite 2245842-16-2 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is an analog of hypoxanthine.
2’-O-(2-Azidoethyl)adenosine V55510 2'-O-(2-Azidoethyl)adenosine 2226475-42-7 2'-O-(2-Azidoethyl)adenosine is an analogue of purine nucleoside.
2’-O-(2-Methoxyethyl) inosine V55616 2'-O-(2-Methoxyethyl) inosine 545374-76-3 2'-O-(2-Methoxyethyl) inosine is an analogue of purine nucleoside.
2’-O-(2-Methoxyethyl)-2-aminoadenosine V55788 2'-O-(2-Methoxyethyl)-2-aminoadenosine 256224-13-2 2'-O-(2-Methoxyethyl)-2-aminoadenosine is an analogue of purine nucleoside.
2'-O-(2-Methoxyethyl)-cytidine V52891 2'-O-(2-Methoxyethyl)-cytidine 223777-16-0 2'-O-(2-Methoxyethyl)-cytidine is a synthetic oligonucleotide converted from uridine.
2'-O-(2-Methoxyethyl)-uridine V53066 2'-O-(2-Methoxyethyl)-uridine 223777-15-9 2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide converted from uridine.
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) V52983 2′-O-(2-Methoxyethyl)guanosine (2′-O-MOE-rG) 473278-54-5 2'-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl modified nucleoside, which can be synthesized from 2'-O-(2-methoxyethyl)- 2,6-diaminopurine riboside is generated by enzymatic conversion (adenosine deaminase).
2′-O-2-Propyn-1-ylguanosine V55617 2′-O-2-Propyn-1-ylguanosine 206552-86-5 2′-O-2-Propyn-1-ylguanosine is a guanine nucleoside analog.
2’-O-Acetyl-3’,5’-bis-O-benzoyl-6-aza-xylo uridine V55499 2'-O-Acetyl-3',5'-bis-O-benzoyl-6-aza-xylo uridine 161615-21-0 2'-O-Acetyl-3',5'-bis-O-benzoyl-6-aza-xylo uridine is an analogue of purine nucleoside.
2’-O-Acetyl-3’-azido-5’-O-(4-methylbenzoyl)-3’-deoxyuridine V55861 2'-O-Acetyl-3'-azido-5'-O-(4-methylbenzoyl)-3'-deoxyuridine 256485-42-4 2'-O-Acetyl-3'-azido-5'-O-(4-methylbenzoyl)-3'-deoxyuridine is an analogue of purine nucleoside.
2’-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine V55394 2'-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine 2095417-66-4 2'-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine is an adenine nucleoside analogue.
2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-fluorouridine V55996 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-fluorouridine 2072145-63-0 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-fluorouridine is an analogue of purine nucleoside.
2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-methoxyuridine V55356 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine 2072145-81-2 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine is an analogue of purine nucleoside.
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