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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-methyluridine V55322 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methyluridine 2072145-23-2 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methyluridine is an analogue of purine nucleoside.
2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-trifluoromethyluridine V55491 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-trifluoromethyluridine 2072145-74-3 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-trifluoromethyluridine is an analogue of purine nucleoside.
2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-5-methyl uridine V55967 2'-O-Acetyl-5'-O-benzoyl-3'-O-methyl-5-methyl uridine 2305415-91-0 2'-O-Acetyl-5'-O-benzoyl-3'-O-methyl-5-methyl uridine is a thymidine analogue.
2’-O-Acetyl-N4-benzoyl-5’-O-DMT arabinocytidine 3’-O-phosphoramidite V55943 2'-O-Acetyl-N4-benzoyl-5'-O-DMT arabinocytidine 3'-O-phosphoramidite 675573-97-4 2'-O-Acetyl-N4-benzoyl-5'-O-DMT arabinocytidine 3'-O-phosphoramidite is an analogue of purine nucleoside.
2'-O-Hexadecanyl guanosine V75709 2'-O-Hexadecanyl guanosine 2382942-29-0 2'-O-Hexadecanyl guanosine is an analogue of purine nucleoside.
2’-O-Hexadecanyl-2-aminoadenosine V55571 2'-O-Hexadecanyl-2-aminoadenosine 2382942-28-9 2'-O-Hexadecanyl-2-aminoadenosine is an analogue of purine nucleoside.
2′-O-Hexadecyl-adenosine V55534 2′-O-Hexadecyl-adenosine 211690-85-6 2′-O-Hexadecyl-adenosine is an analogue of purine nucleoside.
2’-O-Me-2-thio-U-3’-phos phoramidite V55566 2'-O-Me-2-thio-U-3'-phosphoramidite 302918-84-9 2'-O-Me-2-thio-U-3'-phos phoramidite is an analogue of purine nucleoside.
2'-O-Me-C(Bz) Phosphoramidite V53017 2'-O-Me-C(Bz) Phosphoramidite 110764-78-8 2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides.
2′-O-Methyl-2-amino-6-chloropurine riboside V55952 2′-O-Methyl-2-amino-6-chloropurine riboside 194034-59-8 6-Chloro-9-(2-O-methyl-beta-D-ribofuranosyl)-9H-purin-2-amine is an analogue of purine nucleoside.
2’-O-Methyl-2-thiouridine V55441 2'-O-Methyl-2-thiouridine 113886-72-9 2'-O-Methyl-2-thiouridine is an analogue of purine nucleoside.
2’-O-Methyl-4-thiouridine V56011 2'-O-Methyl-4-thiouridine 34218-80-9 2'-O-Methyl-4-thiouridine is an analogue of purine nucleoside.
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite V51318 2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite 128219-85-2 2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is an analog of hypoxanthine.
2’-O-Methyl-5’-O-DMTr-5-iodouridine (5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyl-uridine) V55462 2'-O-Methyl-5'-O-DMTr-5-iodouridine (5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyl-uridine) 588691-24-1 2'-O-Methyl-5'-O-DMTr-5-iodouridine is an analogue of purine nucleoside.
2’-O-Methyl-5-hydroxymethyluridine V55328 2'-O-Methyl-5-hydroxymethyluridine 910050-95-2 2'-O-Methyl-5-hydroxymethyluridine is an analogue of purine nucleoside.
2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) V55469 2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) 34218-84-3 2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is an analogue of purine nucleoside.
2’-O-Methyl-5-methyl-4-thiouridine V55856 2'-O-Methyl-5-methyl-4-thiouridine 2095417-26-6 2'-O-Methyl-5-methyl-4-thiouridine is an analogue of purine nucleoside.
2’-O-Methyl-N1-methyladenosine V55365 2'-O-Methyl-N1-methyladenosine 91101-00-7 2'-O-Methyl-N1-methyladenosine is an analogue of purine nucleoside.
2’-O-Methyl-N2,N2-dimethyl-guanosine V55288 2'-O-Methyl-N2,N2-dimethyl-guanosine 113886-73-0 2'-O-Methyl-N2,N2-dimethyl-guanosine is an analogue of purine nucleoside.
2'-O-Methylinosine (2‘-甲氧基肌苷) V55690 2'-O-Methylinosine (2'-methoxyinosine) 3881-21-8 9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-ol (2'-O-methylinosine) is an analogue of purine nucleosides.
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