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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
2’-O-Phthalimidopropyl cytidine V55561 2'-O-Phthalimidopropyl cytidine 165381-50-0 2'-O-Phthalimidopropyl cytidine is an analogue of purine nucleoside.
2’-O-Phthalimidopropyl uridine V55953 2'-O-Phthalimidopropyl uridine 165381-44-2 2'-O-Phthalimidopropyl uridine is an analogue of purine nucleoside.
2'-O-Propargyl A(Bz)-3'-phosphoramidite V55612 2'-O-Propargyl A(Bz)-3'-phosphoramidite 171486-59-2 2'-O-Propargyl A(Bz)-3'-phosphoramidite is an adenine nucleoside analog.
2’-O-Propargyladenosine V55363 2'-O-Propargyladenosine 151390-97-5 2'-O-Propargyladenosine is an adenine nucleoside analog.
2’-O-t-Butyldimethylsilyladenosine V55701 2'-Ot-Butyldimethylsilyladenosine 69504-13-8 2'-Ot-Butyldimethylsilyladenosine is an adenine nucleoside analogue.
2'-OMe-A(Bz) Phosphoramidite V53136 2'-OMe-A(Bz) Phosphoramidite 110782-31-5 2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides.
2'-OMe-G(ibu) Phosphoramidite V53015 2'-OMe-G(ibu) Phosphoramidite 150780-67-9 2'-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides.
2'-β-C-Ethynyladenosine V75924 2'-β-C-Ethynyladenosine 640725-76-4 2'-β-C-Ethynyladenosine is an analogue of purine nucleoside.
2'-β-C-Ethynylcytidine V75945 2'-β-C-Ethynylcytidine 188413-99-2 2'-β-C-Ethynylcytidine is an analogue of purine nucleoside.
2'-β-C-Methyl inosine V75942 2'-β-C-Methyl inosine 374750-32-0 2'-β-C-Methyl inosine is an analogue of purine nucleoside.
2′-β-C-Methyl isoguanosine V75562 2′-β-C-Methyl isoguanosine 714249-83-9 2′-β-C-Methyl isoguanosine is an analogue of purine nucleoside.
2′-β-C-Methyl-2-methoxyadenosine V75762 2′-β-C-Methyl-2-methoxyadenosine 1829554-43-9 2′-β-C-Methyl-2-methoxyadenosine is an adenine nucleoside analog.
2'-β-C-Methyl-2-thiouridine V75908 2'-β-C-Methyl-2-thiouridine 1678507-60-2 2'-β-C-Methyl-2-thiouridine is an analogue of purine nucleoside.
2'-β-C-Methyl-3-deazauridine V75693 2'-β-C-Methyl-3-deazauridine 622379-93-5 2'-β-C-Methyl-3-deazauri dine is an analogue of purine nucleoside.
2'-β-C-Methyl-5-fluorouridine V75665 2'-β-C-Methyl-5-fluorouridine 23643-38-1 2'-β-C-methyl-5-fluorouridine is an analogue of purine nucleoside.
2'-β-C-Methyl-5-methoxyuridine V75532 2'-β-C-Methyl-5-methoxyuridine 2072145-45-8 2'-β-C-Methyl-5-methoxyuridine is an analogue of purine nucleoside.
2'-β-C-Methyl-5-methyluridine V75549 2'-β-C-Methyl-5-methyluridine 119410-84-3 2'-β-C-Methyl-5-methyluridine is an analogue of purine nucleoside.
2'-β-C-Methyl-5-trifluoromethyluridine V75925 2'-β-C-Methyl-5-trifluoromethyluridine 2072145-39-0 2'-β-C-Methyl-5-trifluoromethyluridine is an analogue of purine nucleoside.
2'-β-C-Methyl-6-azauridine V75771 2'-β-C-Methyl-6-azauridine 172605-95-7 2'-β-C-Methyl-6-azauridine is an analogue of purine nucleoside.
2′-β-C-Methyl-beta-D-6-methylpurine riboside V75773 2′-β-C-Methyl-beta-D-6-methylpurine riboside 2095417-06-2 2′-β-C-Methyl-beta-D-6-methylpurine riboside is an analogue of purine nucleoside.
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