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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
3’-F-3’-dG(iBu)-2’-phosphoramidite V55971 3'-F-3'-dG(iBu)-2'-phosphoramidite 2080404-21-1 3'-F-3'-dG(iBu)-2'-phosphoramidite is an analogue of purine nucleoside.
3’-N-Acetyl-3’-amino-3’-deoxy-2’,5’-di-O-acetyluridine V55449 3'-N-Acetyl-3'-amino-3'-deoxy-2',5'-di-O-acetyluridine 2305416-09-3 3'-N-Acetyl-3'-amino-3'-deoxy-2',5'-di-O-acetyluridine is an analogue of purine nucleoside.
3’-N-Acetyl-3’-amino-3’-deoxyuridine V55567 3'-N-Acetyl-3'-amino-3'-deoxyuridine 2305415-89-6 3'-N-Acetyl-3'-amino-3'-deoxyuridine is an analogue of purine nucleoside.
3'-O-(2-Methoxyethyl) uridine V75611 3'-O-(2-Methoxyethyl) uridine 870599-31-8 3'-O-(2-Methoxyethyl) uridine is a uridine analog.
3’-O-(2-Methoxyethyl)-2-aminoadenosine V55678 3'-O-(2-Methoxyethyl)-2-aminoadenosine 256224-02-9 3'-O-(2-Methoxyethyl)-2-aminoadenosine is an adenine nucleoside analog.
3’-O-(2-Methoxyethyl)-2-thiouridine V55784 3'-O-(2-Methoxyethyl)-2-thiouridine 647839-20-1 3'-O-(2-Methoxyethyl)-2-thiouridine is an analogue of purine nucleoside.
3’-O-(2-Methoxyethyl)-5-methylcytidine V55486 3'-O-(2-Methoxyethyl)-5-methylcytidine 2243311-50-2 3'-O-(2-Methoxyethyl)-5-methylcytidine is a cytosine nucleoside analog.
3’-O-(2-Methoxyethyl)-5-methyluridine V55906 3'-O-(2-Methoxyethyl)-5-methyluridine 303197-29-7 3'-O-(2-Methoxyethyl)-5-methyluridine is a thymidine analog.
3’-O-(2-Methoxyethyl)adenosine V55448 3'-O-(2-Methoxyethyl)adenosine 303197-30-0 3'-O-(2-Methoxyethyl)adenosine is an adenine nucleoside analog.
3'-O-(2-Methoxyethyl)cytidine V75735 3'-O-(2-Methoxyethyl)cytidine 2305415-84-1 3'-O-(2-Methoxyethyl)cytidine is a cytosine nucleoside analog.
3’-O-(2-Methoxyethyl)guanosine V56013 3'-O-(2-Methoxyethyl)guanosine 256224-03-0 3'-O-(2-Methoxyethyl)guanosine is a guanine nucleoside analog.
3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine (2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluorouridine) V75727 3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine (2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluorouridine) 1445379-59-8 3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is an analogue of purine nucleoside.
3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl) uridine V75743 3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl) uridine 1345716-52-0 3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl) uridine is a uridine analog.
3’-O-(t-Butyldiphenylsilyl) thymidine V55915 3'-O-(t-Butyldiphenylsilyl) thymidine 83467-48-5 3'-O-(t-Butyldiphenylsilyl) thymidine is an analogue of purine nucleoside.
3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine V75756 3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine 171268-84-1 3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine is a uridine analogue.
3’-O-Acetyl-2’-deoxyuridine V56019 3'-O-Acetyl-2'-deoxyuridine 23197-88-8 3'-O-Acetyl-2'-deoxyuridine is an analogue of purine nucleoside.
3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine V55884 3'-O-Acetyl-N2-iso-Butyroyl-2'-deoxy-guanosine 74925-81-8 3'-O-Acetyl-N2-iso-Butyroyl-2'-deoxy-guanosine is an analogue of purine nucleoside.
3'-O-Acetylthymidine ((2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H )-yl)tetrahydrofuran-3-yl acetate) V75600 3'-O-Acetylthymidine ((2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H )-yl)tetrahydrofuran-3-yl acetate) 21090-30-2 3'-O-Acetylthymidine is an analogue of purine nucleoside.
3'-O-DMTr-thymidine 5'-CE phosphoramidite V55912 3'-O-DMTr-thymidine 5'-CE phosphoramidite 134031-86-0 3'-O-DMTr-thymidine 5'-CE phosphoramidite is an analogue of purine nucleoside.
3’-O-Levulinyl-2’-deoxyadenosine V55568 3'-O-Levulinyl-2'-deoxyadenosine 440327-45-7 3'-O-Levulinyl-2'-deoxyadenosine is an analogue of purine nucleoside.
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