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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
4-Deoxy-xylo-uridine V75597 4-Deoxy-xylo-uridine 63527-47-9 4-Deoxy-xylo-uridine is an analogue of purine nucleoside.
4-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone V75929 4-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone 23220-74-8 4-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone is an analogue of purine nucleoside.
4-Methoxy-1-β-D-ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine V75543 4-Methoxy-1-β-D-ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine 1611486-54-4 4-Methoxy-1-β-D-ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine is an analogue of purine nucleoside.
4-Thio-2’-deoxyuridine (2′-Deoxy-4-thiouridine; 4-Thiodeoxyuridine) V55829 4-Thio-2'-deoxyuridine (2′-Deoxy-4-thiouridine; 4-Thiodeoxyuridine) 5580-20-1 4-Thio-2'-deoxyuridine is an analogue of purine nucleoside.
4-Thiothymidine V55524 4-Thiothymidine 7236-57-9 4-Thiothymidine is an analogue of purine nucleoside.
5’(R)-C-Methyl-2-thiouridine V55966 5'(R)-C-Methyl-2-thiouridine 2305416-01-5 5'(R)-C-Methyl-2-thiouridine is an analogue of purine nucleoside.
5’(R)-C-Methyl-3-deazauridine V55298 5'(R)-C-Methyl-3-deazauridine 2305415-82-9 5'(R)-C-Methyl-3-deazauridine is an analogue of purine nucleoside.
5'(R)-C-Methyl-5-methyluridine V75737 5'(R)-C-Methyl-5-methyluridine 129745-35-3 5'(R)-C-Methyl-5-methyluridine is a thymidine analog.
5'(R)-C-Methyladenosine V75588 5'(R)-C-Methyladenosine 3253-81-4 5'(R)-C-Methyladenosine is an analogue of purine nucleoside.
5’(R)-C-Methylcytidine V55954 5'(R)-C-Methylcytidine 72159-53-6 5'(R)-C-Methylcytidine is a cytosine nucleoside analog.
5’(R)-C-Methylguanosine V51794 5’(R)-C-Methylguanosine 85421-89-2 5’(R)-C-Methylguanosine is an analog of guanosine.
5’(R)-C-Methyluridine V55527 5'(R)-C-Methyluridine 72159-54-7 5'(R)-C-Methyluridine is a uridine analog.
5’-(4,4’-Dimethoxytrityl)-5-methyluridine V55387 5'-(4,4'-Dimethoxytrityl)-5-methyluridine 138239-62-0 5'-(4,4'-Dimethoxytrityl)-5-methyluridine is a thymidine analogue.
5′-Amino-2′,5′-dideoxyuridine V75645 5′-Amino-2′,5′-dideoxyuridine 35959-38-7 5′-Amino-2′,5′-dideoxyuridine is an analogue of purine nucleoside.
5′-Amino-5′-deoxythymidine V55886 5′-Amino-5′-deoxythymidine 25152-20-9 5′-Amino-5′-deoxythymidine is an analogue of purine nucleoside.
5′-Azido-2′,5′-dideoxy-2′-fluorouridine V55334 5′-Azido-2′,5′-dideoxy-2′-fluorouridine 1012080-88-4 5′-Azido-2′,5′-dideoxy-2′-fluorouridine is an analogue of purine nucleoside.
5′-Azido-2′,5′-dideoxyadenosine V55850 5′-Azido-2′,5′-dideoxyadenosine 42204-43-3 5′-Azido-2′,5′-dideoxyadenosine is an analogue of purine nucleoside.
5’-Azido-2’,5’-dideoxyuridine V55434 5'-Azido-2',5'-dideoxyuridine 35959-37-6 5'-Azido-2',5'-dideoxyuridine is an analogue of purine nucleoside.
5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine V55418 5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine 2305415-75-0 5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine is an analogue of purine nucleoside.
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine V75716 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine 2095417-42-6 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine is an analogue of purine nucleoside.
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