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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione V75522 1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione 3370-69-2 1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione is an analogue of purine nucleoside.
1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine V75912 1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine 70421-30-6 1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is an analogue of purine nucleoside.
2',3',5'-Tri-O-(t-butyldimethylsilyl)-4'-C-hydroxymethyl uridine V55670 2',3',5'-Tri-O-(t-butyldimethylsilyl)-4'-C-hydroxymethyl uridine 232588-97-5 2',3',5'-Tri-O-(t-butyldimethylsilyl)-4'-C-hydroxymethyl uridine is a uridine analogue.
2’,3’,5’-Tri-O-acetyl adenosine (Adenosine, 2',3',5'-triacetate) V55650 2',3',5'-Tri-O-acetyl adenosine (Adenosine, 2',3',5'-triacetate) 7387-57-7 2',3',5'-Tri-O-acetyl adenosine is an adenine nucleoside analogue.
2',3',5'-Tri-O-acetyl-2-thiouridine V55362 2',3',5'-Tri-O-acetyl-2-thiouridine 28542-31-6 2',3',5'-Tri-O-acetyl-2-thiouridine is an analogue of purine nucleoside.
2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine V55694 2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine 201421-00-3 2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine is a thymidine analogue.
2’,3’,5’-Tri-O-acetyl-5-(trifluoromethyl)uridine V55951 2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine 84500-34-5 2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine is a thymidine analog.
2’,3’,5’-Tri-O-acetyl-5-cyanouridine V55813 2',3',5'-Tri-O-acetyl-5-cyanouridine 1630743-99-5 2',3',5'-Tri-O-acetyl-5-cyanouridine is a thymidine analog.
2’,3’,5’-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine V55308 2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine 1613530-52-1 2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine is an analogue of purine nucleoside.
2′,3′,5′-Tri-O-acetyl-6-chloroguanosine V55821 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine 16321-99-6 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is an analogue of purine nucleoside.
2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine V55640 2',3',5'-Tri-O-acetyl-6-S-methyl-6-thio-guanosine 80681-58-9 2',3',5'-Tri-O-acetyl-6-S-methyl-6-thio-guanosine is an analogue of purine nucleoside.
2’,3’,5’-Tri-O-acetyl-N3-methyluridine V55325 2',3',5'-Tri-O-acetyl-N3-methyluridine 64623-26-3 2',3',5'-Tri-O-acetyl-N3-methyluridine is a uridine analog.
2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine V55629 2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine 622379-83-3 2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine is an analogue of purine nucleoside.
2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-3-deazauridine V75764 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-3-deazauridine 2072145-54-9 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-3-deazauridine is an analogue of purine nucleoside.
2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-fluorouridine V75932 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-fluorouridine 2072145-49-2 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-fluorouridine is an analogue of purine nucleoside.
2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methoxy uridine V75917 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methoxy uridine 2072145-79-8 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methoxy uridine is an analogue of purine nucleoside.
2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methyl uridine V75531 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methyl uridine 957535-53-4 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methyl uridine is a thymidine analogue.
2’,3’,5’-Tri-O-benzoyl-2-thiouridine V55604 2',3',5'-Tri-O-benzoyl-2-thiouridine 21052-18-6 2',3',5'-Tri-O-benzoyl-2-thiouridine is an analogue of purine nucleoside.
2’,3’,5’-Tri-O-benzoyl-4-thiouridine V55378 2',3',5'-Tri-O-benzoyl-4-thiouridine 15049-50-0 2',3',5'-Tri-O-benzoyl-4-thiouridine is an analogue of purine nucleoside.
2',3',5'-Tri-O-benzoyl-5-azacytidine V55595 2',3',5'-Tri-O-benzoyl-5-azacytidine 28998-36-9 2',3',5'-Tri-O-benzoyl-5-azacytidine is a cytosine nucleoside analog.
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