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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
Doxifluridine-d2 (Ro 21-9738-d2; 5-Fluoro-5'-deoxyuridine-d2; 5'-DFUR-d2) V56569 Doxifluridine-d2 (Ro 21-9738-d2; 5-Fluoro-5'-deoxyuridine-d2; 5'-DFUR-d2) 84258-25-3 Doxifluridine-d2 is the deuterated form of Doxifluridine.
FMAU V55398 FMAU 69256-17-3 FMAU is a thymidine nucleoside analogue.
Fostroxacitabine bralpamide (MIV-818) V35038 Fostroxacitabine bralpamide (MIV-818) 2129993-56-0 Fostroxacitabine bralpamide (MIV-818) is an orally bioactive Troxacitabine-based nucleotide precursor with anti-cancer activities.
Ganciclovir-d5 (BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5) V56308 Ganciclovir-d5 (BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5) 1189966-73-1 Ganciclovir-d5 is the deuterium labelled form of Ganciclovir.
Homouridine V55464 Homouridine 30685-57-5 Homouridine, is a uridine analogue.
I-bu-rG Phosphoramidite V53135 I-bu-rG Phosphoramidite 147201-04-5 I-bu-rG Phosphoramidite is a phosphoramidite monomer used in the preparation /synthesis of nucleotides and nucleic acids.
IBU-DC Phosphoramidite V55162 IBU-DC Phosphoramidite 110522-84-4 IBU-DC Phosphoramidite can be used for the synthesis of synthetic oligonucleotides.
Isocytidine V55585 Isocytidine 489-59-8 2-Amino-1-β-D-ribofuranosyl-4(1H)-pyrimidinone is an analogue of purine nucleoside.
KIN59 (5'-O-Tritylinosine; 5'-O-Trityl-inosine) V51900 KIN59 (5'-O-Tritylinosine; 5'-O-Trityl-inosine) 4152-77-6 KIN59 (5'-O-Tritylinosine) is a potent allosteric inhibitor of thymidine phosphorylase.
L-2'-Fd4C V51889 L-2'-Fd4C 221662-50-6 L-2'-Fd4C is an l-nucleoside analog.
L-Cytidine V55638 L-Cytidine 26524-60-7 L-Cytidine is the L-configuration form of Cytidine .
L-Fd4A V51861 L-Fd4A 210474-65-0 L-Fd4A is an adenine analogue.
L-Guanosine V55603 L-Guanosine 26578-09-6 L-Guanosine is the L-configuration of Guanosine.
L-I-OddU V51857 LI-OddU 207920-87-4 LI-OddU, an L-5'-halo-dioxolane nucleoside analogue, is a potent and specific anti-Epstein-Barr virus (EBV) agent with EC50 of 0.03 μM.
L-Inosine V55944 L-Inosine 21138-24-9 L-Inosine is the L-configuration form of Inosine.
L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) V55994 L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) 21730-93-8 L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is an analogue of purine nucleoside.
Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate V75556 Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate 945684-13-9 Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate is a pyrimidine nucleoside analogue.
Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside V56000 Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside 64363-77-5 Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside is an analogue of purine nucleoside.
Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-beta-D-arabinopentofuranoside V55569 Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-beta-D-arabinopentofuranoside 197647-15-7 Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-beta-D-arabinopentofuranoside is an arabinoside analog.
Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-D-arabinopentofuranoside V75726 Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-D-arabinopentofuranoside 221552-92-7 Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-D-arabinopentofuranoside is a ribofuranosyl nucleoside analog.
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