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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
2’,3’,5’-Tri-O-benzoyl-5-difluoromethyluridine V55536 2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine 2305416-06-0 2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine is a thymidine analogue.
2’,3’,5’-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342) V56012 2',3',5'-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342) 53910-92-2 2',3',5'-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342) is a thymidine analog.
2',3',5'-Tri-O-benzoyl-5-hydroxymethyl-2'-β-C-methyluridine V75544 2',3',5'-Tri-O-benzoyl-5-hydroxymethyl-2'-β-C-methyluridine 2305416-16-2 2',3',5'-Tri-O-benzoyl-5-hydroxymethyl-2'-β-C-methyluridine is a thymidine analogue.
2',3',5'-Tri-O-benzoyl-5-iodouridine V75628 2',3',5'-Tri-O-benzoyl-5-iodouridine 2880-91-3 2',3',5'-Tri-O-benzoyl-5-iodouridine is an analogue of purine nucleoside.
2’,3’,5’-Tri-O-benzoyl-5-methoxyuridine V55986 2',3',5'-Tri-O-benzoyl-5-methoxyuridine 37805-86-0 2',3',5'-Tri-O-benzoyl-5-methoxyuridine is an analogue of purine nucleoside.
2',3',5'-Tri-O-benzoyl-6-azauridine V75681 2',3',5'-Tri-O-benzoyl-6-azauridine 1627-29-8 2',3',5'-Tri-O-benzoyl-6-azauridine is an analogue of purine nucleoside.
2’,3’,5’-Tri-O-benzyl-4’-thio-arabinouridine V55948 2',3',5'-Tri-O-benzyl-4'-thio-arabinouridine 267665-69-0 2',3',5'-Tri-O-benzyl-4'-thio-arabinouridine is an analogue of purine nucleoside.
2′,3′-Anhydroadenosine V55790 2′,3′-Anhydroadenosine 2627-64-7 2′,3′-Anhydroadenosine is an analogue of purine nucleoside.
2’,3’-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine V55811 2',3'-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine 2305415-94-3 2',3'-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine is an analogue of purine nucleoside.
2’,3’-Bis(O-t-butyldimethylsilyl)-2-thiouridine V55817 2',3'-Bis(Ot-butyldimethylsilyl)-2-thiouridine 2305415-97-6 2',3'-Bis(Ot-butyldimethylsilyl)-2-thiouridine is an analogue of purine nucleoside.
2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-didehydro-5’-deoxyuridine V55636 2',3'-Bis(Ot-butyldimethylsilyl)-4',5'-didehydro-5'-deoxyuridine 128070-78-0 2',3'-Bis(Ot-butyldimethylsilyl)-4',5'-didehydro-5'-deoxyuridine is a uridine nucleoside analogue.
2’,3’-Bis-(O-t-butyldimethylsilyl)uridine V55526 2',3'-Bis-(Ot-butyldimethylsilyl)uridine 69504-12-7 2',3'-Bis-(Ot-butyldimethylsilyl)uridine is an analogue of purine nucleoside.
2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy guanosine V75692 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy guanosine 2389988-71-8 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy guanosine is an analogue of purine nucleoside.
2’,3’-Di-O-acetyl-8-benzyloxy-3’-deoxy-3’-fluoroguanosine V55940 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine 2389988-77-4 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine is an analogue of purine nucleoside.
2',3'-Di-O-acetyl-D-uridine (acetic acid 4-acetoxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl- tetrahydrofuran-3-yl ester) V75648 2',3'-Di-O-acetyl-D-uridine (acetic acid 4-acetoxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl- tetrahydrofuran-3-yl ester) 29108-90-5 2',3'-Di-O-acetyl-D-uridine is an analogue of purine nucleoside.
2′,3′-Di-O-acetylguanosine V53304 2′,3′-Di-O-acetylguanosine 42167-65-7 2′,3′-Di-O-acetylguanosine is a nucleoside analog.
2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine V55956 2',3'-Di-O-isopropylidene-4'-alpha-C-azidouridine 690271-27-3 2',3'-Di-O-isopropylidene-4'-alpha-C-azidouridine is a uridine analog.
2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine V55992 2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine 15379-29-0 2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine is an analogue of purine nucleoside.
2',3'-Didehydro-2',3'-dideoxyuridine V55500 2',3'-Didehydro-2',3'-dideoxyuridine 5974-93-6 2',3'-Didehydro-2',3'-dideoxyuridine is an analogue of purine nucleoside.
2′,3′-Dideoxy-3′-fluoro-5-methylcytidine V75719 2′,3′-Dideoxy-3′-fluoro-5-methylcytidine 115249-95-1 2′,3′-Dideoxy-3′-fluoro-5-methylcytidine is an analogue of purine nucleoside.
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