White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74945 | Nemolizumab (CIM331) | 1476039-58-3 | Nemolizumab (CIM331) is a humanized anti-human interleukin-31 receptor alpha monoclonal antibody (mAb) that can inhibit interleukin-31 (IL-31) binding to its receptor and subsequent signal transduction. |
|
V74994 | Nemvaleukin alfa (ALKS 4230; RDB-1450) | 2315268-27-8 | Nemvaleukin alfa (ALKS 4230) is an IL-2 fusion protein that selectively binds to the medium-affinity IL-2R. |
|
V74996 | Netakimab | 1796570-08-5 | Netakimab is an anti-IL-17 monoclonal antibody (mAb). |
|
V51481 | Nidanilimab (CAN-04) | 2171061-85-9 | Nidanilimab (CAN04) is a fully human monoclonal anti-IL1RAP antibody with a Kd of 1.10 pM. |
|
V75017 | NLRP3-IN-25 | 2660230-90-8 | NLRP3-IN-25 (compound 32) is an orally bioavailable NLRP3 inhibitor (antagonist) with anti-inflammatory activity. |
|
V74943 | Olokizumab (CDP 6038; OKZ) | 1007223-17-7 | Olokizumab (CDP 6038) is a humanized monoclonal antibody (mAb) targeting interleukin-6 (IL-6). |
|
V74975 | Ordesekimab (AMG 714; PRV-015) | 879293-15-9 | Ordesekimab (AMG 714; PRV-015) is a human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody (mAb). |
|
V75039 | OSM-SMI-8 (NSC642624) | 1689690-20-7 | OSM-SMI-8 (NSC642624) is a potent OSM (oncostatin M) antagonist. |
|
V74970 | Oxelumab (R 4930; huMAb OX 40L; Ro 49-89991) | 1186098-83-8 | Oxelumab (R 4930) is a human monoclonal antibody (mAb) targeting OX40 ligand (OX40L). |
|
V73565 | P2X7-IN-2 | 1058709-63-9 | P2X7-IN-2 (compound 58) is a P2X7 receptor blocker/inhibitor. |
|
V76665 | P2X7-IN-2 TFA | P2X7-IN-2 TFA (compound 58) is a P2X7 receptor blocker/inhibitor. | |
|
V56033 | Pegaldesleukin | 141752-91-2 | Pegaldesleukin is a conjugate of polyethylene glycol and interleukin-2 (PEG-IL2). |
|
V74985 | Perakizumab (RG4934; Anti-Human IL17A Recombinant Antibody) | 89957-37-9 | Perakizumab (RG4934) is a humanized IgG1κ monoclonal antibody (mAb) directed against IL-17A (Interleukin Related). |
|
V75046 | Picankibart | 2622900-74-5 | Picankibart is a mouse-derived IgG1κ antibody targeting IL23A. |
|
V74957 | Pivekimab | 2234335-84-1 | Pivekimab is a human IgG1 monoclonal antibody (mAb) targeting interleukin 3 (IL-3) and CD123. |
|
V74926 | Rademikibart (CBP-201) | 2648260-80-2 | Rademikibart (CBP-201) is a human monoclonal antibody (mAb) targeting IL-4Rα with a KD of 20.7 pM when binding to the human IL-4Rα epitope. |
|
V74939 | Reslizumab (Sch 55700) | 241473-69-8 | Reslizumab (Sch 55700) is a humanized monoclonal antibody (mAb) targeting human interleukin-5 (IL-5), used to study eosinophilic asthma. |
|
V74984 | Rilonacept (Arcalyst; IL 1 Trap; Interleukin 1 Trap) | 501081-76-1 | Rilonacept (Arcalyst) is a dimeric fusion protein that is an interleukin-1 inhibitor. |
|
V74932 | Risankizumab (Risankizumab rzaa; BI 655066) | 1612838-76-2 | Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (mAb) that targets the IL-23 p19 subunit (Kd <10 pM) and inhibits human IL-23-induced IL-17 production in mouse splenocytes (IC50 = 2 pM). |
|
V74269 | RO2959 monohydrochloride | 2309172-44-7 | RO2959 mono HCl is a potent and specific CRAC channel inhibitor (antagonist) with IC50 of 402 nM. |
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