White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74999 | Rolinsatamb | 2095467-30-2 | Rolinsatamb is a potent dual (bifunctional) inhibitor of IL-4 and IL-13 and a fully humanized bispecific monoclonal antibody (mAb). |
|
V75027 | Romilkimab (SAR156597) | 1399584-78-1 | Romilkimab (SAR156597) is a chimeric humanized IG antibody that specifically targets IL-4 and IL13. |
|
V76532 | Sarilumab (Anti-Human IL6Rα, Human Antibody) | Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody (mAb). | |
|
V74928 | Secukinumab (AIN457) | 1229022-83-6 | Secukinumab (AIN457) is a high-affinity monoclonal antibody (mAb) directed against interleukin (IL-17A). |
|
V75050 | Shegansu B ((+)-Shegansu B; Parvifolol D) | 291535-65-4 | Shegansu B is an inhibitor (blocker/antagonist) of IL-1β. |
|
V74933 | Siltuximab (CNTO-328) | 541502-14-1 | Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody (mAb) with anti-tumor activity. |
|
V74987 | Simlukafusp alfa (FAP-IL2v) | 1776942-10-9 | Simlukafusp alfa (FAP-IL2v) is an immunocytokine that includes an antibody against fibroblast activation protein alpha (FAPα) and an IL-2 variant that binds only IL-2Rβγ. |
|
V74971 | Sirukumab (CNTO-136; Anti-Human IL6 Recombinant Antibody) | 1194585-53-9 | Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. |
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V74995 | Sonelokimab (solokimab; ALX 0761; M 1095) | 1414386-05-2 | Sonelokimab (ALX 0761; M 1095) is a trivalent Nanobody consisting of monovalent camel-derived Nanobodies specific for human interleukin (IL)-17A, IL-17F and human serum albumin VHH. |
|
V74953 | Spesolimab (BI 655130) | 2097104-58-8 | Spesolimab (BI 655130) is an anti-IL-36R antibody. |
|
V74959 | SRI-42127 | 2727872-68-4 | SRI-42127 is a HuR translocation inhibitor. |
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V74993 | Stapokibart (CM310) | 2734715-10-5 | Stapokibart (CM310) is a humanized monoclonal antibody (mAb) targeting IL-4Rα that effectively blocks the interaction of the cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. |
|
V75006 | Tagraxofusp (SL-401) | 2055491-00-2 | Tagraxofusp (SL-401) is a potent IL-3 receptor blocker/inhibitor that suppresses the growth of plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) microenvironment of multiple myeloma (MM). |
|
V74936 | Talacotuzumab (Talactuzumab; JNJ 56022473; CSL 362) | 1826831-79-1 | Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized CD123-neutralizing monoclonal antibody (mAb) containing a modified Fc structure. |
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V75047 | Temtokibart | 2639874-57-8 | Temtokibart is a humanized IgG1λ2 antibody targeting IL22RA1. |
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V74952 | Tildrakizumab (SCH 900222; MK 3222; Anti-Human IL23 Recombinant Antibody) | 1326244-10-3 | Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody (mAb). |
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V75028 | TNF-α-IN-10 | 2247720-56-3 | TNF-α-IN-10 (compound 8a) is an IL-6 and TNF-α inhibitor. |
|
V74925 | Tocilizumab (Anti-Human IL6R, Humanized Antibody) | 375823-41-9 | Tocilizumab (Anti-Human IL6R, Humanized Antibody) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting classical and trans Signal. |
|
V74951 | Tozorakimab (MEDI-3506) | 2376858-66-9 | Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody (mAb) targeting interleukin-33. |
|
V75022 | Triptoquinone A | 142950-86-5 | Triptoquinone A is an interleukin-1 inhibitor that can suppress endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced Blood vessels relax. |
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