Size | Price | Stock | Qty |
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500mg |
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1g |
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2g |
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5g |
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Other Sizes |
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Pyrantel tartrate, the tartrate salt of pyrantel, is a potent antinematodal and anthelmintic agent with a broad spectrum of activities. It has been used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs).
ln Vitro |
For 72 hours, pyrantel tartrate (10 nM–10 µM) demonstrated strong anti-A antibodies. suum and anti-N (0-168.2 M; 72 h). Activities of American Nus [1][2].
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ln Vivo |
In hamsters infected with Vibrio ceylonali, pyrantel tartrate (10 mg/kg; po; single dose) can reduce the number of worms, reducing the worm burden by 87.2% and deworming rate to 63.4% [2].
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Cell Assay |
Cell viability assay [2]
Cell Types: Nepenthes americana Tested Concentrations: 0-168.2 M (0-100 µg/mL) Incubation Duration: 72 hrs (hours) Experimental Results: Inhibitory effect on third-stage larvae and adults of Nepenthes americana, IC50 The values are 2.0 and 7.6 mg/ml respectively. |
Animal Protocol |
Animal/Disease Models: Male Syrian golden hamster (3 weeks old; A. ceylanicum infection) [2].
Doses: 10 mg/kg Route of Administration: Oral; single. Experimental Results: The worm load reduction rate and deworming rate were 87.2% and 63.4% respectively. |
References |
[1]. Martin RJ, et, al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90.
[2]. Tritten L, et, al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5(12):e1457. |
Molecular Formula |
C11H14N2S.C4H6O6
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Molecular Weight |
356.3941
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CAS # |
33401-94-4
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Related CAS # |
Pyrantel pamoate;22204-24-6;Pyrantel;15686-83-6
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
CN1CCCN=C1/C=C/C2=CC=CS2.O=C(O)[C@H](O)[C@@H](O)C(O)=O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 34 mg/mL (~95.40 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.84 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.84 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.84 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8059 mL | 14.0296 mL | 28.0591 mL | |
5 mM | 0.5612 mL | 2.8059 mL | 5.6118 mL | |
10 mM | 0.2806 mL | 1.4030 mL | 2.8059 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.