| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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Purity: ≥98%
QS11 (QS-11) is a novel and potent inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARF-GAP1) [EC50 of 1.5 µM] with anticancer activity.
| ln Vitro |
It is possible that QS11 controls Wnt/β-catenin signaling via influencing protein trafficking because it binds to and inhibits the GTPase-activating protein ARFGAP1 [1]. In the presence of Wnt-3a conditioned media, QS11 (2.5 μM) can activate the Super(8X)TOPFlash reporter gene 200-fold, whereas Wnt-3a treatment alone can boost reporter gene activity by 40-fold [2]. QS11 has strong anti-HEK293 and human primary fibroblast activity (EC50=0.5 μM) and minimal cytotoxicity [2]. In vitro, QS11 efficiently inhibits the migration of human breast cancer cells that have spread [2].
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| References | |
| Additional Infomation |
(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol is a member of biphenyls.
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| Molecular Formula |
C36H33N5O2
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|---|---|
| Molecular Weight |
567.69
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| Exact Mass |
567.263
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| CAS # |
944328-88-5
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| Related CAS # |
944328-88-5;
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| PubChem CID |
42623900
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
852.2±75.0 °C at 760 mmHg
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| Flash Point |
469.2±37.1 °C
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| Vapour Pressure |
0.0±0.3 mmHg at 25°C
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| Index of Refraction |
1.685
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| LogP |
6.67
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
43
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| Complexity |
842
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C(C1C=CC(C2C=CC=CC=2)=CC=1)N1C=NC2C(=NC(=NC1=2)OC1C=CC2CCCC=2C=1)N[C@H](CO)CC1C=CC=CC=1
|
| InChi Key |
DOKZLKDGUQWMSX-HKBQPEDESA-N
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| InChi Code |
InChI=1S/C36H33N5O2/c42-23-31(20-25-8-3-1-4-9-25)38-34-33-35(40-36(39-34)43-32-19-18-28-12-7-13-30(28)21-32)41(24-37-33)22-26-14-16-29(17-15-26)27-10-5-2-6-11-27/h1-6,8-11,14-19,21,24,31,42H,7,12-13,20,22-23H2,(H,38,39,40)/t31-/m0/s1
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| Chemical Name |
(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol
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| Synonyms |
QS-11 QS11 QS 11
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~176.16 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.40 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.40 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7615 mL | 8.8076 mL | 17.6152 mL | |
| 5 mM | 0.3523 mL | 1.7615 mL | 3.5230 mL | |
| 10 mM | 0.1762 mL | 0.8808 mL | 1.7615 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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