Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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Targets |
mGluR1R (EC50 = 45 nM); mGluR1R (Ki = 10 nM); mGluR2R (IC50 = 108 μM); mGluR2R (Ki = 113 μM); mGluR4R (IC50 = 593 μM); mGluR4R (Ki = 112 μM)
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ln Vitro |
AMPA and metabotropic glutamate receptors are both agonistic sites for quisqualic acid. Squireic acid stimulates both mGluR4R (EC50=593 μM; Ki=112 μM) and mGluR2R (EC50=108 μM; Ki=113 μM) [1].
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References |
[1]. Hugues-Olivier Bertrand, et al. Common and Selective Molecular Determinants Involved in Metabotopic Glutamate Receptor Agonist Activity. J Med Chem. 2002 Jul 18;45(15):3171-83.
[2]. H Bräuner-Osborne, et al. Ligands for Glutamate Receptors: Design and Therapeutic Prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. |
Molecular Formula |
C5H7N3O5
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Molecular Weight |
189.1262
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Exact Mass |
189.03857033
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CAS # |
52809-07-1
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Appearance |
White to off-white solid
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SMILES |
C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1
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InChi Key |
ASNFTDCKZKHJSW-REOHCLBHSA-N
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InChi Code |
InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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Chemical Name |
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~12.5 mg/mL (~66.09 mM)
H2O : ~2 mg/mL (~10.57 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (6.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (6.61 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (6.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 25 mg/mL (132.18 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication (<60°C). |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.2874 mL | 26.4368 mL | 52.8737 mL | |
5 mM | 1.0575 mL | 5.2874 mL | 10.5747 mL | |
10 mM | 0.5287 mL | 2.6437 mL | 5.2874 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.