Ranitidine HCl

Alias: AH19065; Ranitidine Hydrochloride; ZANTAC; AH-19065; AH 19065; Tanidina; Toriol; Fendibina; Gastridina; Sostril; Zantic; Ranisen; Ranitidine HCl

Cat No.:V1211 Purity: ≥98%

COA Product Data Instructions for use SDS

Ranitidine HCl Chemical Structure CAS No.: 66357-59-3
Product category: Histamine Receptor

This product is for research use only, not for human use. We do not sell to patients.

Size	Price	Stock	Qty
500mg
1g
2g
5g
10g
Other Sizes

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Other Forms of Ranitidine HCl:

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Top Publications Citing lnvivochem Products

Nature 2021, 597(7874):119-125.

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J Am Chem Soc 2022,144:21831-21836.

Cell 2020,183:1202-1218.e25.

Science Adv 2022:8,eabm9427.

Nature 2021,597(7874):119-125.

Cell 2020,183:1202-1218.e25.

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Purity & Quality Control Documentation

Current batch：

Purity: ≥98%

COA

MSDS

NMR

Instructions

Product Description
Bioactivity & Protocols
Physicochemical Properties
Solubility Data
Calculators
Clinical Trial Information

Product Description

Ranitidine HCl (ZANTAC; AH-19065; AH 19065; Tanidina; Toriol; Fendibina; Gastridina; Sostril; Zantic; Ranisen), the hydrochloride salt of Ranitidine, is a histamine H2-receptor antagonist with an IC50 of 3.3 ± 1.4 uM. Through the inhibition of stomach acid production, it is used to treat ulcers in the stomach or intestines. While ranitidine HCl does not have this property, it makes hepatocytes more vulnerable to death from cytotoxic products produced by activated neutrophils. When lipopolysaccharide is used to stimulate monocytes in vitro, ranitidine prevents the production of tumor necrosis factor-alpha (TNF-alpha).

Biological Activity I Assay Protocols (From Reference)

Targets

Histamine H2 receptor

ln Vitro

In vitro activity: Ranitidine increases the susceptibility of hepatocytes to death from cytotoxic products produced by activated neutrophils; this is not the case with metronidazole. [1] When lipopolysaccharide is used to stimulate monocytes in vitro, ranitidine prevents the production of tumor necrosis factor-alpha (TNF-alpha). Ranitidine [2] raises the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes and dose-dependently lowers the Kel of morphine with a maximum effect of 50%. The morphine-3-glucuronide/morphine-6-glucuronide ratio is progressively reduced by ranitidine by up to 21%.[3]

ln Vivo

Ranitidine causes liver damage, as shown by elevated serum levels of gamma-glutamyl transferase, aspartate aminotransferase, and alanine aminotransferase in rats administered ranitidine for six hours.[1] Ranitidine inhibits the cytokine-induced neutrophil chemoattractant, the hepatic accumulation of neutrophils, and the increase in hepatic tissue levels of TNF-alpha caused by hepatic ischemia/reperfusion in rats.[2] In rats treated with LPS and RAN, anticoagulants lessen liver damage, while ranitidine cotreatment increases LPS-induced coagulation before liver injury. Rats given ranitidine or LPS develop fibrin clots in their liver sinusoids and are less likely to experience hepatocellular injury due to the prevention of fibrin deposition. In rats, ranitidine cotreatment amplifies the TNF rise brought on by LPS before hepatocellular damage manifests.[4]

Animal Protocol

Rats

References

[1]. J Pharmacol Exp Ther . 2003 Oct;307(1):9-16.

[2]. J Pharmacol Exp Ther . 2002 Jun;301(3):1157-65.

[3]. Pharmacol Toxicol . 1998 Jun;82(6):272-9.

[4]. Toxicol Sci . 2007 Nov;100(1):267-80.

[5]. Neuropharmacology . 1998 Aug;37(8):1019-32.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula

C13H23CLN4O3S

Molecular Weight

350.86

Exact Mass

350.12

Elemental Analysis

C, 44.50; H, 6.61; Cl, 10.10; N, 15.97; O, 13.68; S, 9.14

CAS #

66357-59-3

Related CAS #

Ranitidine-d6 hydrochloride; 1185238-09-8; Ranitidine; 66357-35-5; Ranitidine bismuth citrate; 128345-62-0

Appearance

Solid powder

SMILES

CN/C(=C\[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C.Cl

InChi Key

GGWBHVILAJZWKJ-KJEVSKRMSA-N

InChi Code

InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;

Chemical Name

(E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride

Synonyms

AH19065; Ranitidine Hydrochloride; ZANTAC; AH-19065; AH 19065; Tanidina; Toriol; Fendibina; Gastridina; Sostril; Zantic; Ranisen; Ranitidine HCl

HS Tariff Code

2934.99.9001

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Solubility (In Vitro)

DMSO: 50~70 mg/mL (142.5~199.5 mM)

Water: ~70 mg/mL (~199.5 mM)

Ethanol: <1 mg/mL

Solubility (In Vivo)

Chemical Name: (E)-N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride

InChi Key: GGWBHVILAJZWKJ-KJEVSKRMSA-N

InChi Code: InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;

SMILES Code: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl

(Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8501 mL	14.2507 mL	28.5014 mL
	5 mM	0.5700 mL	2.8501 mL	5.7003 mL
	10 mM	0.2850 mL	1.4251 mL	2.8501 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Mass

Concentration

Volume

Molecular Weight*

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Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

Calculate the Mass of a compound required to prepare a solution of known volume and concentration
Calculate the Volume of solution required to dissolve a compound of known mass to a desired concentration
Calculate the Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?

Enter 350.26 in the Molecular Weight (MW) box
Enter 10 in the Concentration box and choose the correct unit (mM)
Enter 5 in the Volume box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:

Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
Enter 25 into the Concentration (End) box and select the correct unit (mM)
Enter 25 into the Volume (End) box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box

Molecular formula

Total molecular weight

g/mol

Calculate Reset

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4 c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
Click the “Calculate” button
The answer appears in the Volume (to add to vial) box

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)

Dosage mg/kg

Average weight of animals g

Dosing volume per animal μL

Number of animals

Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)

% DMSO

% Tween 80

% ddH₂O

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Calculation results

Working concentration： mg/mL；

Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O，mix and clarify.

Note： (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

Clinical Trial Information

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01131702	Completed	Drug: Ranitidine	Healthy	Dr. Reddy's Laboratories Limited	January 2003	Phase 1
NCT04397445	Completed	Drug: Ranitidine Drug: Placebo Other: Low nitrite/NDMA meals	Ranitidine Adverse Reaction Pharmacokinetics Food-drug Interaction	Food and Drug Administration (FDA)	June 8, 2020	Phase 1
NCT01896557	Completed	Drug: omeprazole Drug: Ranitidine Drug: Clopidogrel	Coronary Artery Disease Drug Interaction Potentiation	University of Sao Paulo General Hospital	October 2011	Phase 4
NCT02197143	Completed	Drug: esomeprazole Drug: Ranitidine	Dyspepsia	Pamukkale University	March 2013	Phase 4
NCT01737840	Completed	Drug: Pantoprazole Drug: Ranitidine	Dyspepsia	Akdeniz University	October 2012	Phase 4