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Purity: ≥98%
RGD (Arg-Gly-Asp) is a tripeptide that is the most common peptide motif responsible for cell adhesion to the ECM-extracellular matrix. It acts by mimicking cell adhesion proteins and binding to integrins. RGD peptide can also promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing. Cell adhesion proteins called integrins recognize and bind to this sequence, which is found within many matrix proteins, including fibronectin, fibrinogen, vitronectin, osteopontin, and several other adhesive extracellular matrix proteins
| ln Vitro |
The most popular and successful peptide sequence for promoting cell attachment on artificial surfaces is RGD. 24 integrins—α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and, to a lesser extent, α2β1 and α4β1—bind to ECM molecules in an RGD-dependent manner[1].
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| References |
[1]. Hersel U, et al. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003 Nov;24(24):4385-415.
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| Molecular Formula |
C12H22N6O6
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| Molecular Weight |
346.34
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| CAS # |
99896-85-2
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| Related CAS # |
RGD Trifluoroacetate;2378808-45-6
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| SMILES |
O=C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])/N=C(\N([H])[H])/N([H])[H])N([H])[H])N([H])C([H])([H])C(N([H])[C@]([H])(C(=O)O[H])C([H])([H])C(=O)O[H])=O
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| InChi Key |
IYMAXBFPHPZYIK-BQBZGAKWSA-N
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| InChi Code |
IYMAXBFPHPZYIK-BQBZGAKWSA-N
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| Chemical Name |
Arginylglycylaspartic acid
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8873 mL | 14.4367 mL | 28.8734 mL | |
| 5 mM | 0.5775 mL | 2.8873 mL | 5.7747 mL | |
| 10 mM | 0.2887 mL | 1.4437 mL | 2.8873 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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