Size | Price | Stock | Qty |
---|---|---|---|
10mg |
|
||
25mg |
|
||
50mg |
|
||
100mg |
|
||
250mg |
|
||
500mg |
|
||
Other Sizes |
|
Purity: ≥98%
Physcion (also known as Physcione) is a naturally occuring anthraquinone isolated from roots of Rheum officinale Baill. Physcion has been commercialised in China for controlling powdery mildews. Physcion controls powdery mildew mainly through changing the expression of defence-related genes, and especially enhancing expression of leaf-specific thionin in barley leaves. Rhein induces apoptosis in cancer cell lines and inhibits transforming growth factor β-1 induced plasminogen activator inhibitor-1 in endothelial cells.
Targets |
6-phosphogluconate dehydrogenase(IC50=38.5 μM);6-phosphogluconate dehydrogenase(Kd=26.0 μM)
|
||
---|---|---|---|
ln Vitro |
Physcion has been commercialised in China for controlling powdery mildews. Physcion controls powdery mildew mainly through changing the expression of defence-related genes, and especially enhancing expression of leaf-specific thionin in barley leaves
|
||
ln Vivo |
|
||
Animal Protocol |
|
||
References |
Molecular Formula |
C16H12O5
|
|
---|---|---|
Molecular Weight |
284.26
|
|
Exact Mass |
284.07
|
|
Elemental Analysis |
C, 67.60; H, 4.26; O, 28.14
|
|
CAS # |
521-61-9
|
|
Related CAS # |
Physcion-d3;1215751-27-1
|
|
Appearance |
Solid powder
|
|
SMILES |
CC1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(C=C3O)OC)C2=O
|
|
InChi Key |
FFWOKTFYGVYKIR-UHFFFAOYSA-N
|
|
InChi Code |
InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
|
|
Chemical Name |
1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
|
|
Synonyms |
|
|
HS Tariff Code |
2934.99.9001
|
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
|
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO : 2~3.33 mg/mL ( 7.03~11.71 mM)
THF :~2.5 mg/mL (~8.79 mM ) |
|
---|---|---|
Solubility (In Vivo) |
|
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5179 mL | 17.5895 mL | 35.1791 mL | |
5 mM | 0.7036 mL | 3.5179 mL | 7.0358 mL | |
10 mM | 0.3518 mL | 1.7590 mL | 3.5179 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.