| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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Purity: ≥98%
Ribostamycin sulfate (Landamycine, Ribomycine; Ribostamin) is a naturally occuring aminoglycoside-aminocyclitol antibiotic with a broad-spectrum antibiotic activity against various gram-positive and gram-negative bacteria. It is extracted from Streptomyces ribosifidicus. Aminoglycoside class of antibiotics consist of amino groups linked to glycosides, they act by inhibiting protein synthesis via binding to the 30s ribosomal subunit, which results in misreading of the mRNA sequence and inhibition of translocation.
| ln Vitro |
In the biosynthesis of neomycin, ribostamycin serves as an intermediary [1].
Protein disulfide isomerase (PDI) chaperone activity was inhibited by ribostamycin, but isomerase activity was not affected[3]. Drug-resistant strains of cocci and bacilli, as well as gram-positive and gram-negative cocci, can be effectively combatted with ribostamycin. Because it has enzymes that modify aminoglycosides, ribostamycin is particularly effective against the gentamicin-resistant bacteria Klebsiella pneumoniae[3]. |
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| References |
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| Molecular Formula |
C17H36N4O14S
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|---|---|
| Molecular Weight |
552.549
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| Elemental Analysis |
C, 36.95; H, 6.57; N, 10.14; O, 40.54; S, 5.80
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| CAS # |
53797-35-6
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| Related CAS # |
25546-65-0;53797-35-6 (sulfate);
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| Appearance |
Solid powder
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| SMILES |
O=S(O)(O)=O.O[C@@H]([C@H](O)[C@@H](CN)O1)[C@@H](N)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@@]2([H])O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
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| InChi Key |
RTCDDYYZMGGHOE-YMSVYGIHSA-N
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| InChi Code |
InChI=1S/C17H34N4O10.H2O4S/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17;1-5(2,3)4/h4-17,22-27H,1-3,18-21H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+;/m1./s1
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| Synonyms |
Ribomycine; Ribostamin; SF 733 antibioic sulfate;Landamycine, Riboflavine sulfate;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : 100~130 mg/mL (~235.27 mM )
DMSO : < 1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (90.49 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8098 mL | 9.0490 mL | 18.0979 mL | |
| 5 mM | 0.3620 mL | 1.8098 mL | 3.6196 mL | |
| 10 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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