| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
Riluzole hydrochloride is an anticonvulsant medication that falls under the class of use-dependent Na+ channel blockers. It has an IC50 of 43 μM for inhibiting GABA content. Riluzole hydrochloride consistently extended IPSCs but only marginally reduced autologous IPSCs at 20 μM. Furthermore, a substantial, concentration-dependent, and readily reversible increase of the reaction to 2 μM GABA was observed with riluzole hydrochloride. GABA currents exhibited a notable desensitization to 2 μM GABA and riluzole HCl after a sustained co-exposure at higher concentrations, particularly 300 μM. About 60 μM is the EC50 of riluzole hydrochloride for increasing GABA responsiveness [1].
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| ln Vivo |
Systemic injection of riluzole hydrochloride (8 mg/kg, i.p.; n = 6 corresponding) is the standard procedure. In the same group, the duration of ultrasonic induction of vocalizations was longer overall (P<0.05) than the drug-loaded test, although the duration of no vocalizations for one week was lower. When compared to before and after preparation, the systemic treatment of riluzole hydrochloride (8 mg/kg, ip; n = 19 components) dramatically decreased arthritic vocalizations (P <0.05 ~ 0.001).The duration of hearing and ultrasonic vocalizations brought on by fish stimulation is greatly shortened by riluzole hydrochloride.
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| References |
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| Molecular Formula |
C8H6CLF3N2OS
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|---|---|
| Molecular Weight |
270.659249782562
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| Exact Mass |
269.984
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| CAS # |
850608-87-6
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| Related CAS # |
Riluzole;1744-22-5
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| PubChem CID |
6419992
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| Appearance |
White to off-white solid powder
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| LogP |
4.16
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
16
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| Complexity |
238
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
QEAOELIJQRYJJS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
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| Chemical Name |
6-(trifluoromethoxy)-1,3-benzothiazol-2-amine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~369.47 mM)
H2O : ~4.17 mg/mL (~15.41 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6947 mL | 18.4734 mL | 36.9467 mL | |
| 5 mM | 0.7389 mL | 3.6947 mL | 7.3893 mL | |
| 10 mM | 0.3695 mL | 1.8473 mL | 3.6947 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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